Showing papers in "Molecular and Cellular Endocrinology in 2008"

TL;DR: Preclinical evidence, as well as preliminary results from clinical studies suggests that pasireotide is a promising new treatment for patients with symptoms of metastatic carcinoid tumors refractory or resistant to octreotide, de novo or persistent acromegaly, and that pasirotide has the potential to be the first directed medical therapy for Cushing's disease.

TL;DR: Results for the first time show that prostate cancer cells in advanced stages of the disease could synthesize androgens from cholesterol and hence are not dependent upon testicular and/or adrenal androgens.

TL;DR: This review mainly focuses on glial cell line-derived neurotrophic factor (Gdnf), which is produced by Sertoli cells to maintain SSCs self-renewal, and the downstream signaling pathways induced by this crucial growth factor.

TL;DR: The results suggest that BPA may interrupt ovarian steroidogenesis by altering the steroidogenic enzymes.

TL;DR: Estrogen modulates memory-related synaptic plasticity not only slowly but also rapidly in the hippocampus, and ERalpha, but not ERbeta, induces the same enhancement/suppression effects on both spinogenesis and LTD.

TL;DR: It is demonstrated that the available data clearly indicates the predictive potential of molecular biomarkers, supporting the development and regulatory application of simple molecular-based screening assays using small model fish for EDC testing.

TL;DR: Somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer's disease.

TL;DR: The results indicate that the inhibitory effects of adiponectin on steroidogenesis are primarily localized to theca cells and that the response of theca Cells to adiponECTin (i.e., ADIPOR2) may be regulated by LH and IGF-I.

TL;DR: This paper identified rare populations of human endometrial epithelial and stromal colony-forming cells/units (CFU) and side population (SP) cells using functional approaches.

TL;DR: In the adult the beta cell is particularly susceptible to autoimmune-mediated attack and to the toxic metabolic milieu associated with over-eating, and utilises a number of these transcription factors in its defence.

TL;DR: The results demonstrate that some plants contain highly selective estrogens for ERbeta, and isolated liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, which is one of the plants found in MF101.

TL;DR: The sequence of decision points and underlying signaling pathways upon CB1 cannabinoid receptor activation that contribute to neuronal diversification in the developing brain are outlined and how these novel principles affect the formation of complex neuronal networks are discussed.

TL;DR: The present knowledge in the antitumor effect of somatostatin and analogs is reviewed and the perspectives of novel clinical strategies based on somatOSTatin receptor sst2 gene transfer therapy are discussed.

TL;DR: New data is provided on the possible dysregulation of EC levels in organs with endocrine function, involved in energy expenditure, or affected by the consequences of metabolic disorders, obtained from mice fed for 3, 8 and 14 weeks with two different high fat diets with different fatty acid compositions and impact on fasting glucose levels.

TL;DR: The neuroendocrine control of luteinizing hormone is described and isotocin (fish homologue of oxytocin) and activins are regulated by multiple neurotransmitters, which is discussed in light of their roles in reproduction in other species.

TL;DR: DHT inhibits adipogenic differentiation of h MSCs and human preadipocytes through an AR-mediated pathway, but it does not affect the proliferation of either hMSCs or preadendipocytes.

TL;DR: The literature here summarized by use of experimental animal models puts forward that heavy cannabis consumption in adolescence may induce subtle changes in the adult brain circuits ending in altered emotional and cognitive performance, enhanced vulnerability for the use of more harmful drugs of abuse in selected individuals, and may represent a risk factor for developing schizophrenia in adulthood.

TL;DR: A summary of the present knowledge regarding gap junctional communication (GJC) and the ovarian gap junction proteins in normally developing ovaries and under pathological conditions is presented in this review.

TL;DR: In this paper, the import of estrogen receptor β (ERβ) into the mitochondria where it mediates a number of estrogen actions on this vital organelle has been shown to have remarkable effects on mitochondrial function.

TL;DR: It is shown that K is non-estrogenic in vivo and exerts bone anabolic activity with attendant inhibition of bone marrow adipogenesis, and exhibits no estrogenicity at the uterine level.

TL;DR: This review focuses on how the ERalpha(-/AA) model has contributed to the knowledge of ERalpha signaling mechanisms in estrogen regulation of the reproductive axis and sexual behavior.

TL;DR: Lesion of the dopamine (DA) nigrostriatal pathway in animals with 1-methyl 4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) provides a model of PD and this is based on its use in humans as side-product of a drug abuse.

TL;DR: It is suggested that epigenetic marks have to be considered to decipher the physiopathological process of PE and since these marks must be established early and are traceable in the maternal blood flow, they could constitute a diagnosis tool.

TL;DR: Results demonstrate that ER subtypes are differentially regulated by E2, and several brain transcripts decrease upon short-term elevation of circulating E2 levels, and the majority of candidate genes identified by microarray in the hypothalamus decreased.

TL;DR: Experiments in which the arcuate nucleus was damaged by an excitotoxic lesion revealed that hypothalamic Ki SS-1 mRNA was significantly reduced, whereas FAT levels were unaffected, suggesting that regulation of KiSS-1 in FAT is independent of the hypothalamus.

TL;DR: This review will first consider how endogenous cannabinoids signal through cannabinoid receptors and the various forms of synaptic plasticity mediated by endocannabinoids, and the interactions between exogenous cannabinoids such as Delta9-tetrahydrocannabinol andEndocannabinoid-mediated plasticity will be examined.

TL;DR: Evidence supporting that CB2 receptors might represent a key element in the endogenous response against different types of cytotoxic events is reviewed, and that this receptor type may be a clinically promising target for the control of brain damage in neurodegenerative disorders is reviewed.

TL;DR: These findings suggest that new proteins are synthesized to replace degraded proteins while swimming and waiting in the female reproductive tract before fertilization, or produced due to the specific needs of the capacitating spermatozoa.

TL;DR: The study indicated that Wnt/beta-catenin signaling pathway inhibited the adipogenic differentiation potential and alter the cell fate from adipocytes to osteoblasts.

TL;DR: Quantitative real-time reverse-transcriptase PCR (qRT-PCR) analysis showed that EcRA initiates ecdysteroid action by regulation the expression of EcRB and 20E-response genes, suggesting that EcR but not USP isoforms play distinct roles during the larval-pupal metamorphosis.