J
Jan B. van Beilen
Researcher at ETH Zurich
Publications - 10
Citations - 905
Jan B. van Beilen is an academic researcher from ETH Zurich. The author has contributed to research in topics: Pseudomonas putida & Gene. The author has an hindex of 10, co-authored 10 publications receiving 847 citations.
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Journal ArticleDOI
Enzyme technology: an overview
Jan B. van Beilen,Zhi Li +1 more
TL;DR: Rapid technological developments are now stimulating the chemistry and pharma industries to embrace enzyme technology, a trend strengthened by concerns regarding health, energy, raw materials, and the environment.
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Expanding the alkane oxygenase toolbox: new enzymes and applications.
TL;DR: Rational and evolutionary engineering approaches have started to yield more robust and versatile enzyme systems, broadening the alkane oxygenase portfolio, and metagenomic approaches provide access to many novel alkane hydroxylases sequences.
Journal ArticleDOI
Oxidative biotransformations using oxygenases.
Zhi Li,Jan B. van Beilen,Wouter A. Duetz,Andreas Schmid,Anna de Raadt,Herfried Griengl,Bernard Witholt +6 more
TL;DR: Preparative biotransformations have been carried out to synthesize useful pharmaceutical intermediates or chiral synthons on the gram to several-hundred-gram scale, by use of whole cells of wild type or recombinant strains.
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Identification of an Amino Acid Position That Determines the Substrate Range of Integral Membrane Alkane Hydroxylases
Jan B. van Beilen,Theo H. M. Smits,Franz F. Roos,Tobias J. Brunner,Stefanie B. Balada,Martina Röthlisberger,Bernard Witholt +6 more
TL;DR: Site-directed mutagenesis of this position in the Mycobacterium tuberculosis H37Rv AH, which oxidizes C10 to C16 alkanes, to introduce more bulky amino acids changed the substrate range in the opposite direction; L69F and L69W mutants oxidized only C10 and C11 alkanes.
Journal ArticleDOI
Stereoselective Desymmetrizations by Recombinant Whole Cells Expressing the Baeyer–Villiger Monooxygenase from Xanthobacter sp. ZL5: A New Biocatalyst Accepting Structurally Demanding Substrates
Daniela V. Rial,Dario A. Bianchi,Petra Kapitanova,Alenka Lengar,Jan B. van Beilen,Marko D. Mihovilovic +5 more
TL;DR: The substrate profile and stereoselectivity of engineered whole cells overexpressing the Baeyer–Villiger monooxygenase from Xanthobacter sp.