J
Jan Bakker
Researcher at New York University
Publications - 477
Citations - 22670
Jan Bakker is an academic researcher from New York University. The author has contributed to research in topics: Intensive care & Septic shock. The author has an hindex of 69, co-authored 461 publications receiving 18991 citations. Previous affiliations of Jan Bakker include Free University of Brussels & University Medical Center.
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Journal ArticleDOI
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine
Maurizio Cecconi,Daniel De Backer,Massimo Antonelli,Richard Beale,Jan Bakker,Christoph Hofer,Roman Jaeschke,Alexandre Mebazaa,Michael R. Pinsky,Jean-Louis Teboul,Jean Louis Vincent,Andrew Rhodes +11 more
TL;DR: In this article, the authors provide support to the bedside clinician regarding the diagnosis, management and monitoring of circulatory shock, which is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate.
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Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*
Ángel Juan Gordo López,José A. Lorente,Jay S. Steingrub,Jan Bakker,A McLuckie,Sheila Willatts,Michael Brockway,Antonio Anzueto,Laurent Holzapfel,Desmond P. Breen,Michael S. Silverman,Jukka Takala,Jill Donaldson,Carl Arneson,Geraldine Grove,Steven H. Grossman,Robert Grover +16 more
TL;DR: The causes of death in the study were consistent with those expected in patients with septic shock, although there was a higher proportion of cardiovascular deaths and a lower incidence of deaths caused by multiple organ failure in the 546C88 group.
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Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.
Tim C. Jansen,Jasper van Bommel,F. Jeanette Schoonderbeek,Steven Sleeswijk Visser,Johan M. van der Klooster,Alex Lima,Sten P. Willemsen,Jan Bakker +7 more
TL;DR: In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors and this study suggests that initial lactate monitoring has clinical benefit.
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Serial blood lactate levels can predict the development of multiple organ failure following septic shock
TL;DR: In patients with septic shock, serial determinations of blood lactate levels are good predictors of the development of MSOF an death and the duration of lactic acidosis is more important than the initial lactate value.
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Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock
TL;DR: It is concluded that the oxygen-derived variables, Do2 and Vo2, cannot be used as prognostic indicators in human septic shock and, in contrast, blood lactate levels are closely related to ultimate survival from septicshock.