J
Jan Borén
Researcher at University of Gothenburg
Publications - 422
Citations - 34585
Jan Borén is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Apolipoprotein B & Lipoprotein. The author has an hindex of 78, co-authored 391 publications receiving 27918 citations. Previous affiliations of Jan Borén include Sahlgrenska University Hospital & Temple University.
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Journal ArticleDOI
Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia.
Martin Adiels,Marja-Riitta Taskinen,Elias Björnson,Linda Andersson,Niina Matikainen,Sanni Söderlund,Juhani Kahri,Antti Hakkarainen,Antti Hakkarainen,Nina Lundbom,Carina Sihlbom,Annika Thorsell,Haihong Zhou,Kirsi H. Pietiläinen,Chris J. Packard,Jan Borén +15 more
TL;DR: To investigate how apolipoprotein C‐III (apoC‐III) metabolism is altered in subjects with type 2 diabetes, whether the perturbed plasma triglyceride concentrations in this condition are determined primarily by the secretion rate or the removal rate of apoC‐ III is investigated.
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Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin
Matias Ekstrand,Maria Gustafsson Trajkovska,Jeanna Perman-Sundelin,Per Fogelstrand,Martin Adiels,Martin Johansson,Lillemor Mattsson-Hultén,Jan Borén,Max Levin +8 more
TL;DR: The results suggest that within lesions, macrophages produce mainly intracellular ROS whereas smooth muscle cells produce extracellular ROS; this may help explain the lesion stabilizing and anti-inflammatory effects of long term statin treatment.
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Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
TL;DR: An overview of the pathways involved in triglyceride-rich lipoprotein (TRL) assembly and intravascular processing is provided, and how the dysregulation of triglyceride transport can result in hypertriglyceridaemia is discussed.
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Genetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy Subjects
Niina Matikainen,Maria Antonella Burza,Stefano Romeo,Antti Hakkarainen,Martin Adiels,Lasse Folkersen,Per Eriksson,Nina Lundbom,Ewa Ehrenborg,Marju Orho-Melander,Marja-Riitta Taskinen,Jan Borén +11 more
TL;DR: In humans, mild but clinically relevant postprandial hyperlipidemia due to reduced hepatic clearance of remnant TRLs may result from genetic polymorphisms that affect hepatic HSPG.
Journal ArticleDOI
Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL
Lu Li,Pia Stillemark-Billton,Caroline Beck,Pontus Boström,Linda Andersson,Mikael Rutberg,Johanna Ericsson,Björn Magnusson,Denis Marchesan,Anna Ljungberg,Jan Borén,Sven-Olof Olofsson +11 more
TL;DR: EGCG treatment reduced the secretion of both triglycerides and apolipoprotein B-100 (apoB-100) VLDLs but not of transferrin, albumin, or total proteins, indicating that EGCG diverts triglycerides from V LDL assembly to storage in the cytosol.