Jan Hörstrup

TL;DR: Data indicate that Hif‐2 plays an important role in the transcriptional response to hypoxia in vivo, which is not confined to the vasculature and is complementary to rather than redundant with HIF‐1.

TL;DR: In this paper, high-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (01% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hyperoxia) and showed that these treatments led to marked nuclear accumulation of these transcription factors in different renal cell populations.

TL;DR: Kidneys are allocated locally without HLA‐matching to keep cold ischemia short to improve use of older donor kidneys.

TL;DR: Cardiomyocytes and cardiac stromal cells exhibit a marked potential for a prolonged transcriptional response to ischemia mediated by HIF, and the induction of HIF‐1α and ‐2α appears to be complementary rather than solely redundant.

TL;DR: Urinary concentrations of tenascin and TIMP-1 are elevated in association with renal disease and may reflect specific aspects of renal fibrosis.