Jan Steffen Jürgensen

TL;DR: Data indicate that Hif‐2 plays an important role in the transcriptional response to hypoxia in vivo, which is not confined to the vasculature and is complementary to rather than redundant with HIF‐1.

TL;DR: In this paper, high-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (01% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hyperoxia) and showed that these treatments led to marked nuclear accumulation of these transcription factors in different renal cell populations.

TL;DR: In vivo evidence is provided for a constitutive up-regulation of HIF-1alpha in the majority of clear cell renal carcinomas, which leads to more widespread accumulation of this transcription factor than hypoxic stimulation.

TL;DR: Structurally distinct inhibitors of prolyl hydroxylation are capable of inducing HIFα and HIF target genes in vitro and in vivo and induce adaptive responses to hypoxia, including angiogenesis.

TL;DR: The role of hypoxia in the pathogenesis of different types of renal disease remains incompletely understood, and results of animal experiments suggest that this is due to an imbalance in the expression of pro- and antiangiogenic factors.