Jan L. Breslow

TL;DR: The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction and multivariate logistic regression analyses showed that both high-density cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern.

TL;DR: The inverse association of moderate alcohol intake with the risk of myocardial infarction is confirmed and support the view that the effect is mediated, in large part, by increases in both HDL2 and HDL3.

TL;DR: The levels, localization, and characteristics of expression of VCAM-1, ICAM-2, and PECam-1 appear to be differentially regulated, and upregulation of VC AM-1 and ICAM -1 is associated with sites of lesion formation.

TL;DR: A direct and causative relationship between the accumulation of intracellular fatty acid-derived metabolites and insulin resistance mediated via alterations in the insulin signaling pathway is suggested, independent of circulating adipocyte-derived hormones.

TL;DR: Directions for future research include RCTs to confirm the initial trials showing that EPA plus DHA decreases cardiovascular death and additional studies to determine whether this effect is due to EPA, DHA, or the combination; the dosage of the effective components; and whether the mechanism of action in humans is prevention of fatal arrhythmias.