J
Jan L. Nouwen
Researcher at Erasmus University Rotterdam
Publications - 42
Citations - 4941
Jan L. Nouwen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Staphylococcus aureus & Staphylococcal infections. The author has an hindex of 23, co-authored 39 publications receiving 4518 citations. Previous affiliations of Jan L. Nouwen include Erasmus University Medical Center.
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Journal ArticleDOI
The role of nasal carriage in Staphylococcus aureus infections.
Heiman F. L. Wertheim,Damian C. Melles,Margreet C. Vos,Willem B. van Leeuwen,Alex van Belkum,Henri A. Verbrugh,Jan L. Nouwen +6 more
TL;DR: In this paper, the authors present an overview of the current knowledge of the determinants (both human and bacterial) and risks of S aureus nasal carriage, and summarise the population dynamics of SA.
Journal ArticleDOI
Reclassification of Staphylococcus aureus nasal carriage types.
Alex van Belkum,Nelianne J. Verkaik,Corné P. de Vogel,Hélène A. M. Boelens,Jeroen Verveer,Jan L. Nouwen,Henri A. Verbrugh,Heiman F. L. Wertheim,Heiman F. L. Wertheim +8 more
TL;DR: There are only 2 types of nasal carriers: persistent carriers and others, which implies a paradigm shift in understanding of susceptibility to S. aureus nasal elimination kinetics and antistaphylococcal antibody profiles.
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Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus.
Alex van Belkum,Damian C. Melles,Jan L. Nouwen,Willem B. van Leeuwen,Willem J. B. van Wamel,Margreet C. Vos,Heiman F. L. Wertheim,Henri A. Verbrugh +7 more
TL;DR: The present review paper will explore the relevance of a large variety of staphylococcal virulence and colonization factors have been identified as well as a number of host' colonisation and infection susceptibility traits and other environmental factors that define the colonisation or infection state in humans.
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Eradication of Methicillin-Resistant Staphylococcus aureus Carriage: A Systematic Review
Heidi S. M. Ammerlaan,Jan Kluytmans,Heiman F. L. Wertheim,Heiman F. L. Wertheim,Jan L. Nouwen,Marc J.M. Bonten,Marc J.M. Bonten +6 more
TL;DR: Short-term nasal application of mupirocin is the most effective treatment for eradicating methicillin-resistant S. aureus carriage, with an estimated success of rate of 90% 1 week after treatment and approximately 60% after a longer follow-up period.
Journal ArticleDOI
Predicting the Staphylococcus aureus Nasal Carrier State: Derivation and Validation of a “Culture Rule”
Jan L. Nouwen,Alewijn Ott,Marjolein F. Q. Kluytmans-Vandenbergh,Hélène A. M. Boelens,Albert Hofman,Alex van Belkum,Henri A. Verbrugh +6 more
TL;DR: A "culture rule" capable of differentiating between persistent and intermittent or noncarriers that uses a minimum of nasal swab cultures that can be used in studies of determinants and risks of S. aureus nasal carriage is developed.