J
Jan Ole Heller
Researcher at University of Kiel
Publications - 3
Citations - 595
Jan Ole Heller is an academic researcher from University of Kiel. The author has contributed to research in topics: Osmotic nephrosis & Mitochondrial permeability transition pore. The author has an hindex of 3, co-authored 3 publications receiving 494 citations.
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Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
Andreas Linkermann,Jan Hinrich Bräsen,Maurice Darding,Mi Kyung Jin,Ana Belen Sanz,Jan Ole Heller,Federica De Zen,Ricardo Weinlich,Alberto Ortiz,Henning Walczak,Joel M. Weinberg,Douglas R. Green,Ulrich Kunzendorf,Stefan Krautwald +13 more
TL;DR: It is demonstrated that necroptosis in ischemia–reperfusion injury (IRI) in mice occurs as primary organ damage, independent of the immune system, and that mice deficient for RIPK3, the essential downstream partner of RIPK1 in necroPTosis, are protected from IRI.
Journal ArticleDOI
The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice
Andreas Linkermann,Jan Ole Heller,Ágnes Prókai,Joel M. Weinberg,Federica De Zen,Nina Himmerkus,Attila Szabo,Jan Hinrich Bräsen,Ulrich Kunzendorf,Stefan Krautwald +9 more
TL;DR: A murine ischemia/reperfusion injury (IRI)-based approach is introduced that allows induction of CIAKI by a single intravenous application of standard RCM after injury for in vivo studies, and Necrostatin-1 (Nec-1), a specific inhibitor of the receptor-interacting protein 1 (RIP1) kinase domain, prevented osmotic nephrosis and CIAKI.
Journal ArticleDOI
Correction: The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI inmice (J Am Soc Nephrol (2013) 24 (1545-1557))
Andreas Linkermann,Jan Ole Heller,Ágnes Prókai,Joel M. Weinberg,F. De Zen,Nina Himmerkus,Attila Szabo,Jan Hinrich Bräsen,Ulrich Kunzendorf,Stefan Krautwald +9 more