U
Ulrich Kunzendorf
Researcher at University of Kiel
Publications - 133
Citations - 7481
Ulrich Kunzendorf is an academic researcher from University of Kiel. The author has contributed to research in topics: Transplantation & Internal medicine. The author has an hindex of 39, co-authored 118 publications receiving 6351 citations. Previous affiliations of Ulrich Kunzendorf include Leiden University Medical Center & Free University of Berlin.
Papers
More filters
Journal ArticleDOI
Synchronized renal tubular cell death involves ferroptosis
Andreas Linkermann,Rachid Skouta,Nina Himmerkus,Shrikant R. Mulay,Christin Dewitz,Federica De Zen,Ágnes Prókai,Gabriele Zuchtriegel,Fritz Krombach,Patrick Simon Welz,Ricardo Weinlich,Tom Vanden Berghe,Tom Vanden Berghe,Peter Vandenabeele,Peter Vandenabeele,Manolis Pasparakis,Markus Bleich,Joel M. Weinberg,Christoph A. Reichel,Jan Hinrich Bräsen,Ulrich Kunzendorf,Hans-Joachim Anders,Brent R. Stockwell,Douglas R. Green,Stefan Krautwald +24 more
TL;DR: It is demonstrated that renal tubules do not undergo sensitization to necroptosis upon genetic ablation of either FADD or caspase-8 and that the RIPK1 inhibitor necrostatin-1 (Nec-1) does not protect freshly isolated tubules from hypoxic injury, and ferroptosis mediates postischemic and toxic renal necrosis.
Journal ArticleDOI
Everolimus in patients with autosomal dominant polycystic kidney disease.
Gerd Walz,Klemens Budde,Marwan Mannaa,Jens Nürnberger,Christoph Wanner,Claudia Sommerer,Ulrich Kunzendorf,Bernhard Banas,Walter H. Hörl,Nicholas Obermüller,Wolfgang Arns,Hermann Pavenstädt,Jens Gaedeke,Martin Büchert,Christoph May,Harald Gschaidmeier,Stefan Kramer,Kai-Uwe Eckardt +17 more
TL;DR: Within the 2-year study period, everolimus slowed the increase in total kidney volume of patients with ADPKD but did not slow the progression of renal impairment [corrected].
Journal ArticleDOI
Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
Andreas Linkermann,Jan Hinrich Bräsen,Maurice Darding,Mi Kyung Jin,Ana Belen Sanz,Jan Ole Heller,Federica De Zen,Ricardo Weinlich,Alberto Ortiz,Henning Walczak,Joel M. Weinberg,Douglas R. Green,Ulrich Kunzendorf,Stefan Krautwald +13 more
TL;DR: It is demonstrated that necroptosis in ischemia–reperfusion injury (IRI) in mice occurs as primary organ damage, independent of the immune system, and that mice deficient for RIPK3, the essential downstream partner of RIPK1 in necroPTosis, are protected from IRI.
Journal ArticleDOI
Regulated Cell Death in AKI
Andreas Linkermann,Guochun Chen,Guie Dong,Ulrich Kunzendorf,Stefan Krautwald,Zheng Dong,Zheng Dong +6 more
TL;DR: Combination therapy targeting multiple cell-death pathways may, therefore, provide maximal therapeutic benefits in AKI.
Journal ArticleDOI
Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
Andreas Linkermann,Jan Hinrich Bräsen,Nina Himmerkus,Shuya Liu,Tobias B. Huber,Ulrich Kunzendorf,Stefan Krautwald +6 more
TL;DR: Necrostatin-1 reduces organ damage and renal failure, even when administered after reperfusion, resulting in a significant survival benefit in a model of lethal renal ischemia/reperfusion injury and shows the predominance of necroptosis over apoptosis in this setting.