Jan Reyelt

TL;DR: The results of several recent proof-of-principle studies are reviewed that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.

TL;DR: A proof of principle that opens up a new avenue for targeting leukocyte ecto‐enzymes in vivo and that can serve as a model also for developing new antidotes against ADP‐ribosylating toxins is formed.

TL;DR: Two Escherichia coli triple reporter strains designed based on the industrially relevant production host E. coli showed higher sensitivity in response to environmental changes and represent valuable tools to study population heterogeneity in bioprocesses significantly increasing the level of information compared to the use of single reporter strains.

TL;DR: In this paper, it was shown that CroSR391, an ortholog of λ Cro, also serves as a potent transcriptional repressor of rumAB, and that deletion of croSR391 on the native R391 results in a dramatic increase in mutagenesis.

TL;DR: It is concluded that the chromosomally-integrated PLacO3O1 has higher sensitivity to low temperatures, due to longer-lasting super-coiled states, which might partially explain the temperature-sensitivity of some transcriptional programs of E. coli.