S
Stefan Rothenburg
Researcher at University of California, Davis
Publications - 55
Citations - 2212
Stefan Rothenburg is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene & Virus. The author has an hindex of 22, co-authored 45 publications receiving 1752 citations. Previous affiliations of Stefan Rothenburg include Kansas State University & University of California, Berkeley.
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Journal ArticleDOI
Poxviruses and the evolution of host range and virulence.
TL;DR: The biology of poxviruses is reviewed with a focus on host range, zoonotic infections, virulence, genomics and host range genes as well as the current knowledge about the function of poXv virus host range factors and how their interaction with the host innate immune system contributes to poxvirus host range and virulence.
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Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.
TL;DR: ZBP1 was recently identified as a cytosolic pattern recognition receptor of double-stranded DNA, and thus, ZBP1 is proposed as a model for HCMV-mediated IRF3 activation that involves H CMV-associated DNA as the principal innate immune-activating pathogen-associated molecular pattern.
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A PKR-like eukaryotic initiation factor 2α kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains
Stefan Rothenburg,Nikolaus Deigendesch,Katharina Dittmar,Friedrich Koch-Nolte,Friedrich Haag,Ky Lowenhaupt,Alexander Rich,Alexander Rich +7 more
TL;DR: This previously undescribed kinase, designated PKZ (protein kinase containing Z-DNA binding domains), is transcribed constitutively at low levels and is highly induced after injection of poly(inosinic)-poly(cytidylic) acid, which simulates viral infection.
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A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity.
TL;DR: This finding suggests that differences in Z-DNA formation by polymorphic dinucleotide repeats may be one of the factors contributing to genetic variation.
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Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo
Friedrich Koch-Nolte,Jan Reyelt,Britta Schößow,Nicole Schwarz,Felix Scheuplein,Stefan Rothenburg,Friedrich Haag,Vanina Alzogaray,Ana Cauerhff,Fernando Alberto Goldbaum +9 more
TL;DR: A proof of principle that opens up a new avenue for targeting leukocyte ecto‐enzymes in vivo and that can serve as a model also for developing new antidotes against ADP‐ribosylating toxins is formed.