J
Jan Reyelt
Researcher at Bosch
Publications - 8
Citations - 714
Jan Reyelt is an academic researcher from Bosch. The author has contributed to research in topics: Gene & Organism. The author has an hindex of 3, co-authored 8 publications receiving 643 citations. Previous affiliations of Jan Reyelt include University of Hamburg.
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Journal ArticleDOI
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Janusz Wesolowski,Vanina Alzogaray,Jan Reyelt,Mandy Unger,Karla Juarez,Karla Juarez,Mariela Urrutia,Ana Cauerhff,Welbeck Danquah,Björn Rissiek,Felix Scheuplein,Nicole Schwarz,Sahil Adriouch,Olivier Boyer,Michel Seman,Alexei Licea,David V. Serreze,Fernando Alberto Goldbaum,Friedrich Haag,Friedrich Koch-Nolte +19 more
TL;DR: The results of several recent proof-of-principle studies are reviewed that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
Journal ArticleDOI
Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo
Friedrich Koch-Nolte,Jan Reyelt,Britta Schößow,Nicole Schwarz,Felix Scheuplein,Stefan Rothenburg,Friedrich Haag,Vanina Alzogaray,Ana Cauerhff,Fernando Alberto Goldbaum +9 more
TL;DR: A proof of principle that opens up a new avenue for targeting leukocyte ecto‐enzymes in vivo and that can serve as a model also for developing new antidotes against ADP‐ribosylating toxins is formed.
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Development and characterization of Escherichia coli triple reporter strains for investigation of population heterogeneity in bioprocesses
TL;DR: Two Escherichia coli triple reporter strains designed based on the industrially relevant production host E. coli showed higher sensitivity in response to environmental changes and represent valuable tools to study population heterogeneity in bioprocesses significantly increasing the level of information compared to the use of single reporter strains.
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CroSR391, an ortholog of the λ Cro repressor, plays a major role in suppressing polVR391-dependent mutagenesis
John P. McDonald,Dominic R. Quiros,Alexandra Vaisman,Antonio R. Mendez,Jan Reyelt,Marlen Schmidt,Martín Gonzalez,Roger Woodgate +7 more
TL;DR: In this paper, it was shown that CroSR391, an ortholog of λ Cro, also serves as a potent transcriptional repressor of rumAB, and that deletion of croSR391 on the native R391 results in a dramatic increase in mutagenesis.
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Chromosome and plasmid-borne P LacO3O1 promoters differ in sensitivity to critically low temperatures
Samuel M. D. Oliveira,Nadia S. M. Goncalves,Vinodh Kandavalli,Leonardo Fernandes Martins,Ramakanth Neeli-Venkata,Jan Reyelt,José Fonseca,Jason Lloyd-Price,Jason Lloyd-Price,Harald Kranz,André Sanches Ribeiro +10 more
TL;DR: It is concluded that the chromosomally-integrated PLacO3O1 has higher sensitivity to low temperatures, due to longer-lasting super-coiled states, which might partially explain the temperature-sensitivity of some transcriptional programs of E. coli.