J
Jana Lipfert
Researcher at Leipzig University
Publications - 6
Citations - 393
Jana Lipfert is an academic researcher from Leipzig University. The author has contributed to research in topics: Chemokine receptor & Proinflammatory cytokine. The author has an hindex of 6, co-authored 6 publications receiving 367 citations.
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Journal ArticleDOI
Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro.
Susan Kralisch,Sebastian Weise,Grit Sommer,Jana Lipfert,Ulrike Lossner,Matthias Blüher,Michael Stumvoll,Mathias Fasshauer +7 more
TL;DR: It is shown that chemerin is upregulated in fat cells by IL-1beta and might modulate the effects of IL- 1beta on adipocyte metabolism and insulin sensitivity and downregulated insulin-stimulated glucose uptake.
Journal ArticleDOI
The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells
Veysel Ödemis,Jana Lipfert,Robert Kraft,Peter Hajek,Getu Abraham,Kirsten Hattermann,Rolf Mentlein,Jürgen Engele +7 more
TL;DR: Evidence is provided that CXCR7 affects astrocytic cell signaling and function through pertussis toxin‐sensitive Gi/o proteins inAstrocytes, and the demonstration that SDF‐1‐bound CX CR7 activates Gi/O proteins in astroCytes could help to explain some discrepancies previously observed for the function of CxCR4 and CXcr7 in other cell types.
Journal ArticleDOI
CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia.
Jana Lipfert,Veysel Ödemis,Daniel-Christoph Wagner,Johannes Boltze,Johannes Boltze,Jürgen Engele +5 more
TL;DR: Whether primary microglial cells additionally express CXCR7 and if so how this chemokine receptor functions in this cell type is asked.
Journal ArticleDOI
Interleukin-1ß is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro
Susan Kralisch,Grit Sommer,Sebastian Weise,Jana Lipfert,Ulrike Lossner,Manja Kamprad,Kathleen Schröck,Matthias Blüher,Michael Stumvoll,Mathias Fasshauer +9 more
TL;DR: TIARP/STAMP2 is highly upregulated in 3T3‐L1 cells and hMSC‐Ad by IL‐1ß and might, therefore, modulate proinflammatory and insulin resistance‐inducing effects of IL‐ 1ß.
Journal ArticleDOI
Amyloid precursor protein expression is induced by tumor necrosis factor α in 3T3‐L1 adipocytes
Grit Sommer,Susan Kralisch,Jana Lipfert,Sebastian Weise,Kerstin Krause,Beate Jessnitzer,Ulrike Lossner,Matthias Blüher,Michael Stumvoll,Mathias Fasshauer +9 more
TL;DR: A potent upregulation of APP by TNF α is shown for the first time suggesting a potential role of this adipocyte‐secreted protein in TNFα‐induced insulin resistance and inflammatory disease.