J
Jane E. Collins
Researcher at University of Southampton
Publications - 56
Citations - 3256
Jane E. Collins is an academic researcher from University of Southampton. The author has contributed to research in topics: Tight junction & Hepatic stellate cell. The author has an hindex of 28, co-authored 56 publications receiving 2913 citations. Previous affiliations of Jane E. Collins include National Institute for Medical Research & Newcastle University.
Papers
More filters
Journal ArticleDOI
Defective epithelial barrier function in asthma.
Chang Xiao,Sarah M. Puddicombe,Sarah A. Field,Joel Haywood,Victoria Broughton-Head,Ilaria Puxeddu,Hans Michael Haitchi,Elizabeth Vernon-Wilson,David Sammut,Nicole Bedke,Catherine Cremin,Jody Sones,Ratko Djukanovic,Peter H. Howarth,Jane E. Collins,Stephen T. Holgate,Phillip Monk,Donna E. Davies +17 more
TL;DR: The results show that the bronchial epithelial barrier in asthma is compromised, which may facilitate the passage of allergens and other agents into the airway tissue, leading to immune activation and may thus contribute to the end organ expression of asthma.
Journal ArticleDOI
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
Shyam Prasad,Roberto Mingrino,Katri Kaukinen,Katherine L Hayes,Robert M. Powell,Thomas T. MacDonald,Jane E. Collins +6 more
TL;DR: It is suggested that INFγ/TNFα and IL-13 have differential effects on CL 2, 3 and 4 in tight junctions, which may lead to increased permeability via different mechanisms.
Journal ArticleDOI
Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains.
TL;DR: The results support the previous model for the transmembrane organization of dg2 and 3 and suggest that these glycoproteins are specialized for calcium-dependent adhesion in their extracellular domains and, cytoplasmically, for the molecular interactions involved in desmosome plaque formation.
Journal ArticleDOI
Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.
Bhavwanti Sheth,Ira Fesenko,Jane E. Collins,Breda Moran,Arthur E. Wild,James M. Anderson,Tom P. Fleming +6 more
TL;DR: Results provide direct evidence from a native epithelium that ZO-1 isoforms perform distinct roles in tight junction assembly and may act as a final rate-limiting step in the synthesis of the tight junction, thereby regulating the time of junction sealing and blastocoele formation in the early embryo.
Journal ArticleDOI
Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.
TL;DR: The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment and abnormalities in this structure are discussed.