R
Robert M. Powell
Researcher at University of Southampton
Publications - 28
Citations - 3361
Robert M. Powell is an academic researcher from University of Southampton. The author has contributed to research in topics: ADAM33 & Bronchial hyperresponsiveness. The author has an hindex of 19, co-authored 28 publications receiving 3198 citations. Previous affiliations of Robert M. Powell include Southampton General Hospital.
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Journal ArticleDOI
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Peter A. B. Wark,Sebastian L. Johnston,Fabio Bucchieri,Robert M. Powell,Sarah M. Puddicombe,Vasile Laza-Stanca,Stephen T. Holgate,Donna E. Davies +7 more
TL;DR: A causal link between deficient interferon-β, impaired apoptosis and increased virus replication is demonstrated, suggesting a novel use for type I interferons in the treatment or prevention of virus-induced asthma exacerbations.
Journal ArticleDOI
Airway remodeling in asthma: New insights
TL;DR: An alternative view of asthma pathogenesis is discussed by emphasizing the importance of the airway microenvironment (the epithelial mesenchymal trophic unit) in the origins of the disease by supporting the recent identification of ADAM33 as an asthma susceptibility gene.
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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
Shyam Prasad,Roberto Mingrino,Katri Kaukinen,Katherine L Hayes,Robert M. Powell,Thomas T. MacDonald,Jane E. Collins +6 more
TL;DR: It is suggested that INFγ/TNFα and IL-13 have differential effects on CL 2, 3 and 4 in tight junctions, which may lead to increased permeability via different mechanisms.
Journal ArticleDOI
Invariant Natural Killer T Cells in Asthma and Chronic Obstructive Pulmonary Disease
Pandurangan Vijayanand,Grégory Seumois,Chris Pickard,Robert M. Powell,Gilbert Angco,David Sammut,Stephan D. Gadola,Peter S. Friedmann,Ratko Djukanovic +8 more
TL;DR: Investigating the frequency of invariant natural killer T cells in the airways of subjects with mild or moderately severe asthma and whether an increased number of these cells is a feature of chronic obstructive pulmonary disease (COPD) found them in low numbers.
Journal ArticleDOI
Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke.
Audrey Richter,Rory A. O'Donnell,Robert M. Powell,Michael W. Sanders,Stephen T. Holgate,Ratko Djukanovic,Donna E. Davies +6 more
TL;DR: The data indicate that secretion of IL-8 in response to CSE is dependent on EGFR activation and that autocrine production of TGF-alpha makes a substantial contribution to this response.