Janet Cox-Singh

TL;DR: In this article, the small subunit ribosomal RNA and the circumsporozoite protein genes were sequenced for eight isolates that had been microscopically identified as P knowlesi by microscopy.

TL;DR: In the absence of a specific routine diagnostic test for P. knowlesi malaria, patients who reside in or have traveled to Southeast Asia and who have received a "P. malariae" hyperparasitemia diagnosis by microscopy receive intensive management as appropriate for severe falciparum malaria.

TL;DR: The nested PCR assay described is a sensitive technique for collecting accurate malaria epidemiologic data when coupled with simple blood spot sampling, it is particularly useful for screening communities in remote regions of the world.

TL;DR: Clinical and laboratory data were collected from previously untreated, nonpregnant adults admitted to the hospital with polymerase chain reaction-confirmed acute malaria at Kapit Hospital (Sarawak, Malaysia) from July 2006 through February 2008 to study the presentation and course of patients with acute P. knowlesi infection.

TL;DR: The results indicate that human infections with P. knowlesi are not newly emergent in Southeast Asia and that knowlesi malaria is primarily a zoonosis with wild macaques as the reservoir hosts, however, ongoing ecological changes resulting from deforestation, with an associated increase in the human population, could enable this pathogenic species of Plasmodium to switch to humans as the preferred host.