Janet M. Cameron

TL;DR: Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed and provide an example of the power of rational, computer-assisted drug design, indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.

TL;DR: 3TC did not significantly affect metabolism of deoxynucleotides in the U937 cell line, and was shown to be resistant to the action of human platelet pyrimidine nucleoside phosphorylase.

TL;DR: The intracellular concentration of 3TC 5'-triphosphate in phytohaemagglutinin (PHA)-stimulated peripheral blood lymphocytes (PBL) shows a linear dependence on the extracellular concentration, which may explain the low levels of mitochondrial toxicity observed with 3TC.

TL;DR: Carbocyclic-9-(2′-deoxy-2′ −β-fluoroarabinofuranosyl) guanine (8) and the corresponding furanose compound (12) have been synthesized; the former compound [which was resolved by formation of the monophosphate (20) and enantioselective hydrolysis using a 5′-nucleotidase] is an extremely potent inhibitor of herpes simplex viruses types 1 and 2.

TL;DR: A novel class of 1,3-oxathiolane nucleoside analogues which were evaluated for anti-HIV activity in the MT-4 cell line have been developed and BCH-371, the adenine derivative, has been found to exhibit significant anti- HIV activity.