M
Mark von Itzstein
Researcher at Griffith University
Publications - 278
Citations - 10806
Mark von Itzstein is an academic researcher from Griffith University. The author has contributed to research in topics: Sialic acid & Sialidase. The author has an hindex of 41, co-authored 263 publications receiving 9749 citations. Previous affiliations of Mark von Itzstein include Monash University, Parkville campus & Monash University, Clayton campus.
Papers
More filters
Journal ArticleDOI
Rational design of potent sialidase-based inhibitors of influenza virus replication.
Mark von Itzstein,Wen-Yang Wu,Gaik B. Kok,Michael S. Pegg,Jeffrey Clifford Dyason,Betty Jin,Tho Van Phan,Mark L. Smythe,Hume Forrest White,Hume Forrest White,Stuart W. Oliver,Peter M. Colman,Joseph N. Varghese,D. Michael Ryan,Jacqueline M. Woods,Richard C. Bethell,Vanessa J. Hotham,Janet M. Cameron,Charles R. Penn +18 more
TL;DR: Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed and provide an example of the power of rational, computer-assisted drug design, indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
Journal ArticleDOI
Unravelling the Role of O-glycans in Influenza A Virus Infection
Juliane Mayr,Kam Lau,Jimmy C. C. Lai,Ivan A. Gagarinov,Yun Shi,Sarah McAtamney,Renee W. Y. Chan,John M. Nicholls,Mark von Itzstein,Thomas Haselhorst +9 more
TL;DR: It is suggested that sialylated Galβ(1,3)GalNAc as O-glycan core 1 glycoforms are involved in the influenza A virus life cycle and play a particularly crucial role during infection of HPAI strains.
Journal ArticleDOI
The war against influenza: discovery and development of sialidase inhibitors.
TL;DR: A historical perspective on the discovery and development of two inhibitors of sialidase — zanamivir and oseltamiviral — is provided and highlights the value of structure-based drug design in this process.
Journal ArticleDOI
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
S. Horsefield,H. Burdett,Xiaoxiao Zhang,Xiaoxiao Zhang,M.K. Manik,Yun Shi,J. Chen,J. Chen,Tiancong Qi,Jonathan Gilley,Jonathan Gilley,Jhih Siang Lai,M. Rank,Lachlan W. Casey,W. Gu,Daniel J. Ericsson,G. Foley,R.O. Hughes,Todd Bosanac,Mark von Itzstein,John P. Rathjen,Jeffrey D. Nanson,Mikael Bodén,Ian B. Dry,Simon J. Williams,Brian J. Staskawicz,Michael P. Coleman,Michael P. Coleman,Thomas Ve,Thomas Ve,Peter N. Dodds,Bostjan Kobe +31 more
TL;DR: NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells, and Toll/interleukin-1 receptor (TIR) domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD+) as part of their cell-death signaling in response to pathogens.