M
Mark L. Smythe
Researcher at University of Queensland
Publications - 65
Citations - 6427
Mark L. Smythe is an academic researcher from University of Queensland. The author has contributed to research in topics: Cyclic peptide & Linker. The author has an hindex of 26, co-authored 65 publications receiving 6099 citations. Previous affiliations of Mark L. Smythe include Monash University, Parkville campus & Washington University in St. Louis.
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Journal ArticleDOI
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
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Rational design of potent sialidase-based inhibitors of influenza virus replication.
Mark von Itzstein,Wen-Yang Wu,Gaik B. Kok,Michael S. Pegg,Jeffrey Clifford Dyason,Betty Jin,Tho Van Phan,Mark L. Smythe,Hume Forrest White,Hume Forrest White,Stuart W. Oliver,Peter M. Colman,Joseph N. Varghese,D. Michael Ryan,Jacqueline M. Woods,Richard C. Bethell,Vanessa J. Hotham,Janet M. Cameron,Charles R. Penn +18 more
TL;DR: Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed and provide an example of the power of rational, computer-assisted drug design, indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
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VALIDATE: A New Method for the Receptor-Based Prediction of Binding Affinities of Novel Ligands
Richard D. Head,Mark L. Smythe,Tudor I. Oprea,Chris L. Waller,Stuart M. Green,Garland R. Marshall +5 more
TL;DR: VALIDATE is a hybrid approach to predict the binding affinity of novel ligands for receptors of known three-dimensional structure that calculates physicochemical properties of the ligand and the receptor - ligand complex to estimate the free energy of binding.
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Toward larger chemical libraries: Encoding with fluorescent colloids in combinatorial chemistry
Bronwyn J. Battersby,Darryn Bryant,Wim Meutermans,Daniel R. Matthews,Mark L. Smythe,Matt Trau +5 more
TL;DR: This work introduces an encoding method that involves physically attaching fluorescent colloidal particles to the surface of solid support beads during split and mix syntheses, to produce an information-rich, colored barcode that can be easily, rapidly, and inexpensively decoded using fluorescence microscopy.
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Proteolytic degradation of host hemoglobin by schistosomes.
Paul J. Brindley,Bernd H. Kalinna,John P. Dalton,Sharon R. Day,Joanna Y.M. Wong,Joanna Y.M. Wong,Mark L. Smythe,Donald P. McManus +7 more
TL;DR: This paper reviews reports dating from 40 years ago to the present on how schistosomes digest host-derived hemoglobin, and interprets apparent anomalies in some earlier compared to later reports, the latter having benefited from the availability of PCR and gene cloning technologies.