Janet Maud Rowson

TL;DR: STELA analysis of human XpYp telomeres in fibroblasts identifies several features of telomere biology and indicates that unexpectedly large-scale differences in zygoticTelomere length are maintained throughout development.

TL;DR: It is shown that despite the majority of telomeres being maintained at a stable length in normal human cells, a subset of stochastically shortened telomereres can potentially cause chromosomal instability and thus are fusogenic.

TL;DR: An analysis of both genome-wide telomere length and single molecule analysis of specific chromosome ends in human sperm observation may have implications for the genetic determination of ageing, genetic disease and fertility.

TL;DR: Analysis of telomeres of 2p, 11q, 12q, 17p and XpYp suggests that physiological levels of telomerase allow differential telomere length regulation and indicates the presence of cis-acting factors that govern both telomeric stability and chromosome-specific telomee length in the presenceOf the telomees analysed, thetelomere of 17p was more stable with a striking paucity of large-scale length changes, and exhibited the shortest recorded

TL;DR: Additional barriers to clonal expansion intermediate between M1 and M2 are described, revealed by abrogation of tumor-suppressor gene (TSG) pathways by individual human papillomavirus type 16 (HPV16) proteins, providing a model for clonal evolution by successive TSG inactivation and suggesting that cell type diversity in life span regulation may determine the pattern of gene mutation in the corresponding tumors.