Stephen Man

TL;DR: Examination of the clinical and environmental safety and immunogenicity in the first clinical trial of a live recombinant vaccinia virus expressing the E6 and E7 proteins of HPV 16 and 18 found vaccination resulted in no significant clinical side-effects and there was no environmental contamination by live TA-HPV.

TL;DR: It is shown that despite the majority of telomeres being maintained at a stable length in normal human cells, a subset of stochastically shortened telomereres can potentially cause chromosomal instability and thus are fusogenic.

TL;DR: In this paper, the authors identified HLA-A*0201-restricted peptide-specific CTLs in the peripheral blood (four of five patients), draining lymph nodes (three of four patients) and tumors (one of three patients) of cervical cancer patients.

TL;DR: It is shown that gene gun-mediated vaccination with an epitope-based DNA vaccine protects 100% of the vaccinated mice against a lethal tumor challenge and the finding that defined flanking sequences around epitopes and protein targeting dramatically increased the efficacy of epitope string DNA vaccines against established tumors will be of importance for the further development of multiepitope DNA vaccines toward clinical application.

TL;DR: A novel tetramer-based technique, based on chimeric HLA A2/H-2Kb H chains, is developed to directly monitor the CTL response to chimeric vaccines in HLA-A2 transgenic mice, and defines a novel vaccination strategy optimized for the induction of an effective polyvalent cytotoxic response.