Janice A. Culpepper

TL;DR: The ob gene product, leptin, is an important circulating signal for the regulation of body weight and a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin fusion proteins were generated to identify high affinity leptin-binding sites in the mouse choroid plexus.

TL;DR: It is predicted that the long intrACEllular domain form of OB-R is crucial for initiating intracellular signal transduction, and as a corollary, the inability to produce this form ofOB-R leads to the severe obese phenotype found in db/db mice.

TL;DR: It is proposed that neurotactin represents a new δ-chemokine family and that it may play a role in brain inflammation processes.

TL;DR: The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning and is a candidate for a previously reported diet-induced obesity quantitative trait locus on mouse chromosome 7.