John S. Smutko

TL;DR: The ob gene product, leptin, is an important circulating signal for the regulation of body weight and a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin fusion proteins were generated to identify high affinity leptin-binding sites in the mouse choroid plexus.

TL;DR: In this paper, the authors profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry.

TL;DR: A theoretical evaluation of marker-assisted congenic production is presented and empirical data that support it are provided and this ‘speed congenic’ method is presented in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenicProduction.

TL;DR: The results demonstrate the existence of additional IL-1 gene family members within the previously definedIL-1 cluster and point to this region of chromosome 2 as an evolutionary hotspot for IL-2 gene duplication and may prove to have an important role in inflammatory responses.

TL;DR: Congenic analysis showed genetic segregation of the two loci of melastatin, a novel gene, whose expression is inversely correlated with melanoma aggressiveness, on mouse chromosome 7 and in the 15q13-q14 region of the human genome.