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Xun Weng
Researcher at Millennium Pharmaceuticals
Publications - 4
Citations - 6371
Xun Weng is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Leptin receptor & Fusion protein. The author has an hindex of 4, co-authored 4 publications receiving 6232 citations.
Papers
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Journal ArticleDOI
Identification and expression cloning of a leptin receptor Ob-R
Louis A. Tartaglia,Marlene Dembski,Xun Weng,Nanhua Deng,Janice A. Culpepper,Rene Devos,Grayson J. Richards,L. Arthur Campfield,Frederick T. Clark,Jim Deeds,Craig Muir,Sean Sanker,Ann Moriarty,Karen J. Moore,John S. Smutko,Gail G. Mays,Elizabeth A. Wool,Cheryl A. Monroe,Robert I. Tepper +18 more
TL;DR: The ob gene product, leptin, is an important circulating signal for the regulation of body weight and a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin fusion proteins were generated to identify high affinity leptin-binding sites in the mouse choroid plexus.
Journal ArticleDOI
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.
Hong Chen,Olga Charlat,Louis A. Tartaglia,Elizabeth A. Woolf,Xun Weng,Stephen J Ellis,Nathan D Lakey,Janice A. Culpepper,Karen J More,Roger E. Breitbart,Geoffrey M. Duyk,Robert I. Tepper,Jay P. Morgenstern +12 more
TL;DR: It is predicted that the long intrACEllular domain form of OB-R is crucial for initiating intracellular signal transduction, and as a corollary, the inability to produce this form ofOB-R leads to the severe obese phenotype found in db/db mice.
Journal ArticleDOI
Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.
Ruth E. Gimeno,Marlene Dembski,Xun Weng,Nanhua Deng,Andrew W. Shyjan,Carlos J. Gimeno,Francois Iris,Stephen J Ellis,Elizabeth A. Woolf,Louis A. Tartaglia +9 more
TL;DR: Observations suggest that UCPH, like UCP, uncouples oxidative phosphorylation and the possibility that the U CPH protein is an important mediator of human thermogenesis is discussed.
Patent
Nucleic acid molecules encoding GLUTX and uses thereof
Louis A. Tartaglia,Xun Weng +1 more
TL;DR: In this paper, the human gene encoding GLUTX, a glucose transporter, was described and used in the diagnosis and treatment of disorders associated with aberrant hexose transport, and molecules which increase or decrease expression or activity of the transporter were identified.