J
Janusz Krawczyk
Researcher at National University of Ireland, Galway
Publications - 57
Citations - 460
Janusz Krawczyk is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 10, co-authored 47 publications receiving 287 citations. Previous affiliations of Janusz Krawczyk include University Hospital Galway & National University of Ireland.
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Journal ArticleDOI
Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells
Areechun Sotthibundhu,Areechun Sotthibundhu,Katya McDonagh,Alex von Kriegsheim,Amaya Garcia-Munoz,Agnieszka Klawiter,Kerry Thompson,Kapil Dev Chauhan,Janusz Krawczyk,Veronica McInerney,Peter Dockery,Michael J. Devine,Michael J. Devine,Tilo Kunath,Frank Barry,Timothy O'Brien,Sanbing Shen +16 more
TL;DR: It is demonstrated that human iPSCs express high basal levels of autophagy, including key components of APMKα, ULK1/2, BECLIN-1, ATG13, ATg101, AtG12, AT G3, ATGs5, and LC3B, which highlights the potential of rapamycin in producing uniform EBs and in shortening iPSC differentiation duration.
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NRXN1 deletion syndrome; phenotypic and penetrance data from 34 families
Maryam Al Shehhi,Eva B. Forman,Jacqueline Fitzgerald,Veronica McInerney,Janusz Krawczyk,Sanbing Shen,David R. Betts,Linda Mc Ardle,Kathleen M. Gorman,Mary D. King,Andrew Green,Louise Gallagher,Sally Ann Lynch +12 more
TL;DR: Pedigree analysis of the inherited group revealed numerous untested relatives with a history of mental health and developmental issues, most notably in the NRXN1β isoform patients.
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AKT as a therapeutic target in multiple myeloma
TL;DR: AKT inhibitors are a welcome addition to the armamentarium against multiple myeloma and promising clinical activity is being reported from ongoing trials in combination with established and/or novel treatment approaches.
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Increased Ca 2+ signaling in NRXN1α +/− neurons derived from ASD induced pluripotent stem cells
Sahar Avazzadeh,Katya McDonagh,Jamie Reilly,Yanqin Wang,Yanqin Wang,Stephanie D. Boomkamp,Veronica McInerney,Janusz Krawczyk,Jacqueline Fitzgerald,Niamh Feerick,Matthew O’Sullivan,Amirhossein Jalali,Eva B. Forman,Sally Ann Lynch,Sean Ennis,Nele Cosemans,Hilde Peeters,Peter Dockery,Timothy O'Brien,Leo R. Quinlan,Louise Gallagher,Sanbing Shen +21 more
TL;DR: This is the first report to show that human NRXN1α+/− neurons derived from ASD patients’ iPSCs present novel phenotypes of upregulated VGCCs and increased Ca2+ transients, which may facilitate the development of drug screening assays for the treatment of ASD.
Journal ArticleDOI
Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma.
Dawn Swan,Mark Gurney,Mark Gurney,Janusz Krawczyk,Janusz Krawczyk,Aideen E. Ryan,Michael O'Dwyer,Michael O'Dwyer +7 more
TL;DR: The effects cyclophosphamide has on the immune system is discussed, and how it can be used synergistically with other treatment modalities including the immunomodulatory agents, monoclonal antibodies and cellular therapies are discussed.