T
Tilo Kunath
Researcher at University of Edinburgh
Publications - 89
Citations - 6854
Tilo Kunath is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 32, co-authored 73 publications receiving 5946 citations. Previous affiliations of Tilo Kunath include Mount Sinai Hospital, Toronto & University of Toronto.
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Promotion of Trophoblast Stem Cell Proliferation by FGF4
TL;DR: A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines that exclusively contributed to the trophoplast lineage in vivo in chimeras.
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FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
Tilo Kunath,Marc K. Saba-El-Leil,Marwa Almousailleakh,Jason Wray,Sylvain Meloche,Austin Smith +5 more
TL;DR: It is established that Fgf4 stimulation of Erk1/2 is an autoinductive stimulus for naïve ES cells to exit the self-renewal programme, and proposed that the Erk cascade directs transition to a state that is responsive to inductive cues for germ layer segregation.
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Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
Michael J. Devine,Mina Ryten,Petr Vodicka,Alison J. Thomson,Tom Burdon,Henry Houlden,Fatima Cavaleri,Masumi Nagano,Masumi Nagano,Nicola J. Drummond,Jan-Willem Taanman,Anthony H.V. Schapira,Katrina Gwinn,John Hardy,Patrick A. Lewis,Tilo Kunath +15 more
TL;DR: This model represents a new experimental system to identify compounds that reduce levels of α- synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.
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Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.
Tilo Kunath,Tilo Kunath,Danielle Arnaud,Gary D. Uy,Ikuhiro Okamoto,Corinne Chureau,Yojiro Yamanaka,Edith Heard,Richard L. Gardner,Philip Avner,Janet Rossant,Janet Rossant +11 more
TL;DR: Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage.
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe H.R. Ludtmann,Marthe H.R. Ludtmann,Plamena R. Angelova,Mathew H. Horrocks,Mathew H. Horrocks,Minee L. Choi,Minee L. Choi,Margarida Rodrigues,Artyom Y. Baev,A. V. Berezhnov,Zhi Yao,Zhi Yao,Daniel Little,Blerida Banushi,Afnan Saleh Al-Menhali,Rohan T. Ranasinghe,Daniel R. Whiten,Ratsuda Yapom,Karamjit Singh Dolt,Michael J. Devine,Paul Gissen,Tilo Kunath,Morana Jaganjac,Evgeny Pavlov,David Klenerman,Andrey Y. Abramov,Sonia Gandhi,Sonia Gandhi +27 more
TL;DR: It is shown that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease.