J
Jared C. Roach
Researcher at Institute for Systems Biology
Publications - 74
Citations - 8741
Jared C. Roach is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Population. The author has an hindex of 37, co-authored 68 publications receiving 8033 citations. Previous affiliations of Jared C. Roach include University of Washington & Seattle Children's Research Institute.
Papers
More filters
Journal ArticleDOI
Genomic Analysis of the Olfactory Receptor Region of the Mouse and Human T-Cell Receptor α/δ Loci
Robert P. Lane,Jared C. Roach,Inyoul Lee,Cecilie Boysen,Arian F.A. Smit,Barbara J. Trask,Leroy Hood +6 more
TL;DR: A comparative genomic analysis of the mouse and human OR clusters that are found 5′ to the TCR genes in both species is provided and reveals no strong sequence conservation, TATA-boxes, or conserved transcription initiator sites in OR promoter regions.
Journal ArticleDOI
Analysis of sequence-tagged-connector strategies for DNA sequencing.
Andrew F. Siegel,Barbara J. Trask,Jared C. Roach,Gregory G. Mahairas,Leroy Hood,Ger van den Engh +5 more
TL;DR: It is estimated that establishing the resource of STCs as a means of identifying minimally overlapping clones represents only 1%-3% of the total cost of sequencing the human genome, and, up to a point of diminishing returns, a larger STC resource is associated with a smaller total sequencing cost.
Journal ArticleDOI
A clade of trypsins found in cold-adapted fish.
TL;DR: The primary sequences of group III trypsins permit insight into function and mechanisms of cold adaption, and the techniques employed are broadly applicable to phylogenies characterized by a markedly different, or “fast‐evolving,” clade.
Journal ArticleDOI
Identification of copy number variants in whole-genome data using Reference Coverage Profiles.
Gustavo Glusman,Alissa Severson,Varsha Dhankani,Max Robinson,Terry Farrah,Denise E. Mauldin,Anna B Stittrich,Seth A. Ament,Jared C. Roach,Mary E. Brunkow,Dale L. Bodian,Joseph G. Vockley,Ilya Shmulevich,John Niederhuber,Leroy Hood +14 more
TL;DR: A method to identify CNVs in individual genomes, based on comparison to joint profiles pre-computed from a large set of genomes, is developed and the increased sensitivity and specificity for individual genome analysis is expected to be critical for achieving clinical-grade genome interpretation.
Journal ArticleDOI
Sequence-Level Analysis of the Major European Huntington Disease Haplotype
Jong-Min Lee,Jong-Min Lee,Kyung Hee Kim,Aram Shin,Michael J. Chao,Kawther Abu Elneel,Tammy Gillis,Jayalakshmi S. Mysore,Julia A. Kaye,Hengameh Zahed,Ian H. Kratter,Aaron C. Daub,Steven Finkbeiner,Hong Li,Jared C. Roach,Nathan Goodman,Leroy Hood,Richard H. Myers,Marcy E. MacDonald,Marcy E. MacDonald,James F. Gusella,James F. Gusella +21 more
TL;DR: Confirmation of new CAG-expansion mutations on this haplotype suggests that unlike most founders of human disease, the common ancestor of HD-affected families with the major haplotype most likely did not have HD.