J
Jared C. Roach
Researcher at Institute for Systems Biology
Publications - 74
Citations - 8741
Jared C. Roach is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Population. The author has an hindex of 37, co-authored 68 publications receiving 8033 citations. Previous affiliations of Jared C. Roach include University of Washington & Seattle Children's Research Institute.
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Journal ArticleDOI
Low-pass sequencing for microbial comparative genomics
Young Ah Goo,Jared C. Roach,Gustavo Glusman,Nitin S. Baliga,Kerry Deutsch,Min Pan,Sean Kennedy,Shiladitya DasSarma,Wailap Victor Ng,Leroy Hood +9 more
TL;DR: Identification of multiple TBP and TFB homologs in these four halophiles are consistent with the hypothesis that different types of complex transcriptional regulation may occur through multiple T BP-TFB combinations in response to rapidly changing environmental conditions.
Journal ArticleDOI
The Innate Immune Database (IIDB)
Martin Korb,Alistair G. Rust,Vesteinn Thorsson,Christophe Battail,Bin Li,Daehee Hwang,Kathleen A. Kennedy,Jared C. Roach,Carrie M. Rosenberger,Mark Gilchrist,Daniel E. Zak,Carrie D. Johnson,Bruz Marzolf,Alan Aderem,Ilya Shmulevich,Hamid Bolouri +15 more
TL;DR: The Innate Immune Database (IIDB) is presented as a community resource for immunologists interested in gene regulatory systems underlying innate responses to pathogens and is intended to be broadly applicable to immunology.
Journal ArticleDOI
Population-specific genetic modification of Huntington's disease in Venezuela.
Michael J. Chao,Kyung Hee Kim,Ju Wan Shin,Diane Lucente,Vanessa C. Wheeler,Hong Li,Jared C. Roach,Leroy Hood,Nancy S. Wexler,Laura Bannach Jardim,Peter Holmans,Lesley Jones,Michael Orth,Seung Kwak,Marcy E. MacDonald,Marcy E. MacDonald,James F. Gusella,James F. Gusella,Jong-Min Lee,Jong-Min Lee +19 more
TL;DR: A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington's disease (HD) onset in Europeans, but not explaining the earlier age at onset in these Venezuelans.
Journal ArticleDOI
A third approach to gene prediction suggests thousands of additional human transcribed regions.
Gustavo Glusman,Shizhen Qin,M. Raafat El-Gewely,Andrew F. Siegel,Jared C. Roach,Leroy Hood,Arian F.A. Smit +6 more
TL;DR: A third orthogonal approach to gene prediction, based on detecting the genomic signatures of transcription, accumulated over evolutionary time is presented, which will help identify functional transcripts within many apparent “genomic deserts.”
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Origin of the PSEN1 E280A mutation causing early–onset Alzheimer’s disease
Matthew A. Lalli,Hannah C. Cox,Mary Luz Arcila,Liliana Cadavid,Sonia Moreno,Gloria María Gallego García,Lucia Madrigal,Eric M. Reiman,Mauricio Arcos-Burgos,Mauricio Arcos-Burgos,Gabriel Bedoya,Mary E. Brunkow,Gustavo Glusman,Jared C. Roach,Leroy Hood,Kenneth S. Kosik,Francisco Lopera +16 more
TL;DR: A mutation in presenilin 1 (E280A) causes early‐onset Alzheimer's disease and the origin of this mutation will inform medical genetics.