J
Jared C. Roach
Researcher at Institute for Systems Biology
Publications - 74
Citations - 8741
Jared C. Roach is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Population. The author has an hindex of 37, co-authored 68 publications receiving 8033 citations. Previous affiliations of Jared C. Roach include University of Washington & Seattle Children's Research Institute.
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Journal ArticleDOI
Parent-of-origin-specific signatures of de novo mutations
Jakob M. Goldmann,Wendy S.W. Wong,Michele Pinelli,Terry Farrah,Dale L. Bodian,Anna B Stittrich,Gustavo Glusman,Lisenka E.L.M. Vissers,Alexander Hoischen,Jared C. Roach,Joseph G. Vockley,Joris A. Veltman,Joris A. Veltman,Benjamin D. Solomon,Benjamin D. Solomon,Christian Gilissen,John E. Niederhuber +16 more
TL;DR: It is shown that the number of DNMs in offspring increases not only with paternal age, but also with maternal age, and that some genome regions show enrichment for maternally derived DNMs.
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Endotoxin recognition: In fish or not in fish?
TL;DR: This analysis questions the existence of TLR4‐mediated cellular responses to LPS in fish and speculate that other receptors, in particular beta‐2 integrins, may play a primary role in the activation of piscine leukocytes by LPS.
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Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.
Stephen A. Ramsey,Sandy L. Klemm,Daniel E. Zak,Kathleen A. Kennedy,Vesteinn Thorsson,Bin Li,Mark Gilchrist,Elizabeth S. Gold,Carrie D. Johnson,Vladimir Litvak,Garnet Navarro,Jared C. Roach,Carrie M. Rosenberger,Alistair G. Rust,Natalya Yudkovsky,Alan Aderem,Ilya Shmulevich +16 more
TL;DR: A novel regulator (TGIF1) that may have a role in macrophage activation was identified and a novel statistical test was developed to assess the significance of the time-lagged correlation.
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KAVIAR: an accessible system for testing SNV novelty
TL;DR: Kaviar is presented, a tool that greatly simplifies the assessment of novel variants and includes an integrated and growing database of genomic variation from diverse sources, including over 55 million variants from personal genomes, family genomes, transcriptomes, SNV databases and population surveys.
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TFCat: the curated catalog of mouse and human transcription factors
Debra L. Fulton,Saravanan Sundararajan,Gwenael Badis,Timothy P. Hughes,Wyeth W. Wasserman,Jared C. Roach,Robert Sladek +6 more
TL;DR: TFCat is a catalog of mouse and human TFs based on a reliable core collection of annotations obtained by expert review of the scientific literature that is annotated within a function-based taxonomy and DNA-binding proteins are organized within a classification system.