Jared M. Saletin

TL;DR: The consequences of sleep deprivation on attention and working memory, positive and negative emotion, and hippocampal learning are reviewed, and how this evidence informs mechanistic understanding of the known changes in cognition and emotion associated with SD is explored.

TL;DR: It is found that age-related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep–dependent memory retention, suggesting that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age- related cognitive decline in later life.

TL;DR: It is shown that β-amyloid burden in medial prefrontal cortex (mPFC) correlates significantly with the severity of impairment in NREM SWA generation, and this data implicate sleep disruption as a mechanistic pathway through which β-Amyloid pathology may contribute to hippocampus-dependent cognitive decline in the elderly.

TL;DR: Cross-descriptive level findings demonstrate that the unique neurobiology of sleep exerts powerful effects on molecular, cellular and network mechanisms of plasticity that govern both initial learning and subsequent long-term memory consolidation.

TL;DR: REM sleep physiology is associated with an overnight dissipation of amygdala activity in response to previous emotional experiences, altering functional connectivity and reducing next-day subjective emotionality.