Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging
Bryce A. Mander,Vikram Rao,Brandon Lu,Jared M. Saletin,John R. Lindquist,Sonia Ancoli-Israel,William J. Jagust,William J. Jagust,Matthew P. Walker,Matthew P. Walker +9 more
TLDR
It is found that age-related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep–dependent memory retention, suggesting that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age- related cognitive decline in later life.Abstract:
Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We found that age- related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep-dependent memory retention. Moreover, this memory impairment was further associated with persistent hippocampal activation and reduced task-related hippocampal-prefrontal cortex functional connectivity, potentially representing impoverished hippocampal-neocortical memory transformation. Together, these data support a model in which age-related mPFC atrophy diminishes SWA, the functional consequence of which is impaired long-term memory. Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age-related cognitive decline in later life.read more
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Journal ArticleDOI
Sleep and Human Aging
TL;DR: Do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?
Journal ArticleDOI
Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep
Nina E. Fultz,Nina E. Fultz,Giorgio Bonmassar,Kawin Setsompop,Robert Stickgold,Robert Stickgold,Bruce R. Rosen,Jonathan R. Polimeni,Laura D. Lewis,Laura D. Lewis +9 more
TL;DR: A coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep is discovered, demonstrating that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and theseCSF dynamics are interlinked with neural and hemodynamic rhythms.
Journal ArticleDOI
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Bryce A. Mander,Shawn M. Marks,Jacob W. Vogel,Vikram Rao,Brandon Lu,Jared M. Saletin,Sonia Ancoli-Israel,William J. Jagust,William J. Jagust,Matthew P. Walker,Matthew P. Walker +10 more
TL;DR: It is shown that β-amyloid burden in medial prefrontal cortex (mPFC) correlates significantly with the severity of impairment in NREM SWA generation, and this data implicate sleep disruption as a mechanistic pathway through which β-Amyloid pathology may contribute to hippocampus-dependent cognitive decline in the elderly.
Journal ArticleDOI
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
TL;DR: Cross-descriptive level findings demonstrate that the unique neurobiology of sleep exerts powerful effects on molecular, cellular and network mechanisms of plasticity that govern both initial learning and subsequent long-term memory consolidation.
Journal ArticleDOI
Glymphatic failure as a final common pathway to dementia.
TL;DR: The ties that bind sleep, aging, Glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.
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