T
Ted Abel
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 271
Citations - 23620
Ted Abel is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 74, co-authored 249 publications receiving 21228 citations. Previous affiliations of Ted Abel include Children's Hospital of Philadelphia & Howard Hughes Medical Institute.
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Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
TL;DR: It is demonstrated that treatment of hippocampal slices from BDNF knockout mice with recombinant BDNF completely reverses deficits in long-term potentiation and significantly improves deficits in basal synaptic transmission at the Schaffer collateral-CA1 synapse, indicating that BDNF has an acute role in hippocampal synaptic function.
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Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
Ted Abel,Peter V. Nguyen,Mark Barad,Thomas A.S Deuel,Eric R. Kandel,Roussoudan Bourtchouladze +5 more
TL;DR: In transgenic mice that express R(AB), an inhibitory form of the regulatory subunit of PKA, only in the hippocampus and other forebrain regions, hippocampal PKA activity was reduced, and L-LTP was significantly decreased in area CA1, without affecting basal synaptic transmission or the early phase of LTP.
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Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
TL;DR: It was found that the induction of L-LTP was selectively prevented when transcription was blocked immediately after tetanization or during application of cAMP, suggesting that the late phase of LTP in the CA1 region requires transcription during a critical period.
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Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Michael M. Halassa,Michael M. Halassa,Cédrick Florian,Tommaso Fellin,James R. Munoz,So-Young Lee,So-Young Lee,Ted Abel,Philip G. Haydon,Philip G. Haydon,Marcos G. Frank +10 more
TL;DR: It is concluded that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.
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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
Christopher G. Vecsey,Joshua D. Hawk,K. Matthew Lattal,Joel M. Stein,Sara A. Fabian,Michelle A. Attner,Sara M. Cabrera,Conor B. McDonough,Paul K. Brindle,Ted Abel,Marcelo A. Wood +10 more
TL;DR: It is shown that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-bindingprotein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB -binding domain of CBP.