J
Jari Metso
Researcher at Minerva Foundation Institute for Medical Research
Publications - 85
Citations - 2353
Jari Metso is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Cholesterol & Phospholipid transfer protein. The author has an hindex of 28, co-authored 83 publications receiving 2180 citations. Previous affiliations of Jari Metso include University of Helsinki & National Institute for Health and Welfare.
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Journal ArticleDOI
The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion
TL;DR: Phospholipid transfer protein mediates conversion of high-density lipoprotein (HDL3) to large particles, with concomitant release of apolipoprotein A-I (apoA-I), and a model for PLTP-mediated enlargement of HDL particles is presented.
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Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive.
Tomoichiro Oka,Takeshi Kujiraoka,Mayumi Ito,Tohru Egashira,Sadao Takahashi,M. Nazeem Nanjee,Norman E. Miller,Jari Metso,Vesa M. Olkkonen,Christian Ehnholm,Matti Jauhiainen,Hiroaki Hattori +11 more
TL;DR: Analysis of the size-exclusion chromatography fractions demonstrated that PLTP exists in the circulation as an active population that elutes in the position of HDL corresponding to an average molecular mass of 160+/-40 kDa and an inactive form with an average mass of 520+/-120 kDa, suggesting that the PLTP activity in circulation is modulated by the plasma lipoprotein profile and lipid composition.
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Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).
Minna Kärkkäinen,Tomoichiro Oka,Vesa M. Olkkonen,Jari Metso,Hiroaki Hattori,Matti Jauhiainen,Christian Ehnholm +6 more
TL;DR: Analysis of the two forms of PLTP by SDS-PAGE, Western blotting, immunoprecipitation, and gel filtration demonstrates that LA-PLTP is complexed with apoA-I whereas HA- PLTP is not.
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Oxysterol Binding Protein Induces Upregulation of SREBP-1c and Enhances Hepatic Lipogenesis
Daoguang Yan,Markku Lehto,Laura Rasilainen,Jari Metso,Christian Ehnholm,Seppo Ylä-Herttuala,Matti Jauhiainen,Vesa M. Olkkonen +7 more
TL;DR: It is demonstrated that OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
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Apolipoprotein A-IV Polymorphism in the Finnish Population: Gene Frequencies and Description of a Rare Allele
TL;DR: The apolipoprotein A-IV (apoA-IV) allele frequencies were determined in 387 adult Finns by immunoblotting after isoelectric focusing of serum by determining the phenotypes of 147 mother-child pairs in accordance with the two allelic modes of inheritance.