J
Jason Leigh Vincent
Researcher at Syngenta
Publications - 15
Citations - 295
Jason Leigh Vincent is an academic researcher from Syngenta. The author has contributed to research in topics: Gene cluster & Heterologous expression. The author has an hindex of 7, co-authored 15 publications receiving 176 citations.
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Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production.
Hannah E. Hodgson,Ricardo De La Peña,Michael J. Stephenson,Ramesha B. Thimmappa,Jason Leigh Vincent,Elizabeth S. Sattely,Elizabeth S. Sattely,Anne Osbourn +7 more
TL;DR: The characterization of protolimonoid biosynthetic enzymes from different plant species is reported and supports the notion of pathway conservation between both plant families.
Journal ArticleDOI
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis
Katherine Williams,Agnieszka J. Szwalbe,Nicholas Phillip Mulholland,Jason Leigh Vincent,Andy M. Bailey,Christine L. Willis,Thomas J. Simpson,Russell J. Cox +7 more
TL;DR: The results reveal that the precursors for cyclization are formed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together with two citrate‐processing enzymes.
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Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi.
Agniezka J. Szwalbe,Katherine Williams,Zhongshu Song,Kate M. J. de Mattos-Shipley,Jason Leigh Vincent,Andy M. Bailey,Christine L. Willis,Russell J. Cox,Russell J. Cox,Thomas J. Simpson +9 more
TL;DR: In this article, two dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone.
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Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi.
Claudio Greco,Kate M. J. de Mattos-Shipley,Andy M. Bailey,Nicholas Phillip Mulholland,Jason Leigh Vincent,Christine L. Willis,Russell J. Cox,Thomas J. Simpson +7 more
TL;DR: Three novel dimeric xanthones, cryptosporioptides A–C were isolated from Cryptosporuopsis sp.
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Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 – an insight into the biosynthesis of maleidrides
Agnieszka J. Szwalbe,Katherine Williams,Daniel E. O’Flynn,Andy M. Bailey,Nicholas Phillip Mulholland,Jason Leigh Vincent,Christine L. Willis,Russell J. Cox,Thomas J. Simpson +8 more
TL;DR: In this article, the generic term maleidrides is proposed to encompass biosynthetically-related compounds containing maleic anhydride moieties fused to an alicyclic ring, varying in size and substituents.