J
Jason P. Burgess
Researcher at Research Triangle Park
Publications - 69
Citations - 1502
Jason P. Burgess is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Metabolite & Alkyl. The author has an hindex of 21, co-authored 69 publications receiving 1395 citations. Previous affiliations of Jason P. Burgess include RTI International & Virginia Tech.
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Journal ArticleDOI
Metabolism and hemoglobin adduct formation of acrylamide in humans
Timothy R. Fennell,Susan Sumner,Rodney W. Snyder,Jason P. Burgess,Rebecca Spicer,William E. Bridson,Marvin A. Friedman +6 more
TL;DR: It is indicated that humans metabolize AM via glycidamide to a lesser extent than rodents, and dermal uptake was approximately 6.6% of that observed with oral uptake.
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Novel Bioactive Clerodane Diterpenoids from the Leaves and Twigs of Casearia sylvestris
Nicholas H. Oberlies,Jason P. Burgess,Hernán A. Navarro,R E Pinos,Craig R. Fairchild,Peterson Rw,Djaja D. Soejarto,Norman R. Farnsworth,AD Kinghorn,Mansukh C. Wani,Monroe E. Wall +10 more
TL;DR: Three novel clerodane diterpenoids, casearvestrins A-C (1-3), displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay.
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Kinetics of Elimination of Urinary Metabolites of Acrylamide in Humans
TL;DR: It is indicated that skin provides a barrier that slows the absorption of AM, and results in limited systemic availability following dermal exposure to AM.
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New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Feras Q. Alali,Tamam El-Elimat,Chen Li,Amjad M. Qandil,Ahmad S. Alkofahi,Khaled Tawaha,Jason P. Burgess,Yuka Nakanishi,David J. Kroll,Hernán A. Navarro,Joseph O. Falkinham,Mansukh C. Wani,Nicholas H. Oberlies +12 more
TL;DR: One of these colchicinoids isolated has a novel ring system, to which it is ascribed the trivial name (+)-demecolcinone (9), and it represents the first naturally occurring dextrorotatory col chicinoid.
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A Hexacyclic ent-Trachylobane Diterpenoid Possessing an Oxetane Ring from Mitrephora glabra
Chen Li,Dongho Lee,Tyler N. Graf,Sharnelle S. Phifer,Yuka Nakanishi,Jason P. Burgess,Soedarsono Riswan,Fransisca M. Setyowati,Achmad M. Saribi,Djaja D. Soejarto,Norman R. Farnsworth,Joseph O. Falkinham,David J. Kroll,A. Douglas Kinghorn,Mansukh C. Wani,Nicholas H. Oberlies +15 more
TL;DR: Three new ent-trachylobane diterpenoids were isolated and structures elucidated from Mitrephora glabra Scheff, which possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachyloblanes.