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Yuka Nakanishi
Researcher at Research Triangle Park
Publications - 10
Citations - 794
Yuka Nakanishi is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Boraginaceae & Flavonolignan. The author has an hindex of 9, co-authored 10 publications receiving 720 citations. Previous affiliations of Yuka Nakanishi include University of Jordan & Virginia Tech.
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Journal ArticleDOI
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro
Meredith T. Morgan,Yuka Nakanishi,David J. Kroll,Aaron P. Griset,Michael A. Carnahan,Michel Wathier,Nicholas H. Oberlies,Govindarajan Manikumar,Mansukh C. Wani,Mark W. Grinstaff +9 more
TL;DR: Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle.
Journal ArticleDOI
Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
Paula R. Davis-Searles,Yuka Nakanishi,Nam-Cheol Kim,Tyler N. Graf,Nicholas H. Oberlies,Mansukh C. Wani,Monroe E. Wall,Rajesh Agarwal,David J. Kroll +8 more
TL;DR: Silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells and, among the pure compounds, isosilybin B was again the most effective.
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New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Feras Q. Alali,Tamam El-Elimat,Chen Li,Amjad M. Qandil,Ahmad S. Alkofahi,Khaled Tawaha,Jason P. Burgess,Yuka Nakanishi,David J. Kroll,Hernán A. Navarro,Joseph O. Falkinham,Mansukh C. Wani,Nicholas H. Oberlies +12 more
TL;DR: One of these colchicinoids isolated has a novel ring system, to which it is ascribed the trivial name (+)-demecolcinone (9), and it represents the first naturally occurring dextrorotatory col chicinoid.
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A Hexacyclic ent-Trachylobane Diterpenoid Possessing an Oxetane Ring from Mitrephora glabra
Chen Li,Dongho Lee,Tyler N. Graf,Sharnelle S. Phifer,Yuka Nakanishi,Jason P. Burgess,Soedarsono Riswan,Fransisca M. Setyowati,Achmad M. Saribi,Djaja D. Soejarto,Norman R. Farnsworth,Joseph O. Falkinham,David J. Kroll,A. Douglas Kinghorn,Mansukh C. Wani,Nicholas H. Oberlies +15 more
TL;DR: Three new ent-trachylobane diterpenoids were isolated and structures elucidated from Mitrephora glabra Scheff, which possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachyloblanes.
Journal ArticleDOI
Bioactive Constituents of the Stem Bark of Mitrephora glabra
Chen Li,Dongho Lee,Tyler N. Graf,Sharnelle S. Phifer,Yuka Nakanishi,Soedarsono Riswan,Fransisca M. Setyowati,Achmad M. Saribi,Djaja D. Soejarto,Norman R. Farnsworth,Joseph O. Falkinham,David J. Kroll,A. Douglas Kinghorn,Mansukh C. Wani,Nicholas H. Oberlies +14 more
TL;DR: Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids, five polyacetylenic acids/esters, and one aporphine alkaloid, liriodenine.