J
Jason W. H. Wong
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 189
Citations - 8329
Jason W. H. Wong is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 46, co-authored 175 publications receiving 7382 citations. Previous affiliations of Jason W. H. Wong include University of New South Wales & University College Dublin.
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Journal ArticleDOI
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
Tebbe de Vries,William Martelly,Sébastien Campagne,Kevin Sabath,Chris P. Sarnowski,Jason W. H. Wong,Alexander Leitner,Stefanie Jonas,Shalini Sharma,Frédéric H.-T. Allain +9 more
TL;DR: The characterization of the SF3A1-UBL/U1-SL4 complex expands the repertoire of RNA binding domains and reveals the capacity of RGG/RG motifs to bind RNA in a sequence-specific manner.
Journal ArticleDOI
Lamivudine prophylaxis in liver transplantation for hepatitis B in Asians.
Chung Mau Lo,ST Fan,Ching-Lung Lai,Chi-Leung Liu,Man-Fung Yuen,Irene Oi-Lin Ng,Jason W. H. Wong +6 more
TL;DR: This journal issues Proceedings of the XVIIth World Congress of the Transplantation Society, where the aim was to establish a consensus on the future direction of human organ transplantation.
Journal ArticleDOI
Germline epimutations of APC are not associated with inherited colorectal polyposis
Megan P. Hitchins,Catherine M. Suter,Jason W. H. Wong,Kay Cheong,Nicholas J. Hawkins,Barbara A. Leggett,Rodney J. Scott,Allan D. Spigelman,Ian Tomlinson,David I. K. Martin,Robyn L. Ward +10 more
TL;DR: Cases provide evidence that germline epimutations represent a novel mechanism for disease, which can mimic that of a genetic mutation by conferring a similar phenotype, in individuals clinically classified as having HNPCC.
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Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples
TL;DR: This study reveals multiple functional mutations impacting the splicing pathway in Jurkat cells and demonstrates potential benefits of an integrative proteogenomics analysis for high-throughput functional annotation of SNVs in cancer.
Journal ArticleDOI
Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells.
Qing Liu,Julie A. I. Thoms,Andrea Nuñez,Yizhou Huang,Yizhou Huang,Kathy Knezevic,Deborah Packham,Rebecca C. Poulos,Rachel Williams,Dominik Beck,Dominik Beck,Nicholas J. Hawkins,Nicholas J. Hawkins,Robyn L. Ward,Jason W. H. Wong,Luke B. Hesson,Luke B. Hesson,Mathew A. Sloane,Mathew A. Sloane,John E. Pimanda +19 more
TL;DR: A CTCF-bound region within the MLH1-35 enhancer regulatesMLH1 expression in colorectal cells and is worthy of scrutiny in future genetic screening strategies for suspected Lynch syndrome associated with loss of MLH 1 expression.