J
Jaswinder Singh Maras
Publications - 58
Citations - 533
Jaswinder Singh Maras is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 29 publications receiving 323 citations.
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Journal ArticleDOI
Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis
Sukanta Das,Jaswinder Singh Maras,Md. Shabir Hussain,Shvetank Sharma,Paul David,Sukriti Sukriti,Saggere Muralikrishna Shasthry,Rakhi Maiwall,Nirupama Trehanpati,Tej P. Singh,Shiv Kumar Sarin +10 more
TL;DR: In patients with SAH, there is a significant increase in albumin oxidation, and albumin acts as a pro‐oxidant; this promotes oxidative stress and inflammation in SAH patients through activation of neutrophils.
Journal ArticleDOI
Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute-on-chronic liver failure.
Jaswinder Singh Maras,Rakhi Maiwall,H. C. Harsha,Sukanta Das,Md. Shabir Hussain,Chandan Kumar,Chhagan Bihari,Archana Rastogi,Manoj Kumar,Nirupama Trehanpati,Shvetank Sharma,Akhilesh Pandey,Shiv Kumar Sarin +12 more
TL;DR: Whereas expression of iron‐regulatory genes was markedly down‐regulated, genes related to endoplasmic reticulum stress, apoptosis, and inflammation were up‐regulated in ACLF patients, compared to patients with cirrhosis.
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Serum ferritin predicts early mortality in patients with decompensated cirrhosis
Rakhi Maiwall,Suman Kumar,Ashvanee Kumar Chaudhary,Jaswinder Singh Maras,Z. A. Wani,Chandan Kumar,Archana Rastogi,Chhagan Bihari,Chitranshu Vashisht,Shiv Kumar Sarin +9 more
TL;DR: Serum ferritin levels correlate with severity of hepatic decompensation and are associated with early liver related death independent of the MELD score in hospitalized patients with decompensated cirrhosis and could also have a potential therapeutic implication.
Journal ArticleDOI
Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response.
TL;DR: Patients with non-alcoholic fatty liver disease had a significantly less severe liver disease on histopathology and/or fibroScan which may be attributed to anti-oxidant effect of bilirubin.
Journal ArticleDOI
Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis
Jaswinder Singh Maras,Sukanta Das,Sachin Sharma,Sukriti Sukriti,Jitendra Kumar,Ashish Kumar Vyas,Dhananjay Kumar,Adil Bhat,Gaurav Yadav,Manish Chandra Choudhary,Shvetank Sharma,Guresh Kumar,Chhagan Bihari,Nirupma Trehanpati,Rakhi Maiwall,Shiv Kumar Sarin +15 more
TL;DR: The results suggest that iron mediates inflammation through ADAM17 induction, resulting in macrophage activation and increased shedding of TNF-α and sCD163, postulating a therapeutic strategy for SAH patients with iron overload.