J
Javier Carrasco
Researcher at Autonomous University of Barcelona
Publications - 62
Citations - 3093
Javier Carrasco is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Metallothionein & Astrocyte. The author has an hindex of 34, co-authored 61 publications receiving 2947 citations. Previous affiliations of Javier Carrasco include Carlos III Health Institute & Scripps Research Institute.
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Journal ArticleDOI
Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury
Milena Penkowa,Mercedes Giralt,Natalia Lago,Jordi Camats,Javier Carrasco,Joaquin Hernandez,Amalia Molinero,Iain L. Campbell,Juan Hidalgo +8 more
TL;DR: Although in the brain the chronic astrocyte-targeted expression of IL-6 spontaneously induces an inflammatory response causing significant damage, during an acute neuropathological insult such as following traumatic injury, a clear neuroprotective role is evident.
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Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.
TL;DR: The present results indicate MT‐I’+ II as important for neuron survival during KA‐induced seizures, and suggest that both impaired zinc regulation and compromised antioxidant activity contribute to the observed neuropathology of the MT-I‐I‐II‐deficient mice.
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Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Milena Penkowa,Sergi Florit,Mercedes Giralt,Albert Quintana,Amalia Molinero,Javier Carrasco,Juan Hidalgo +6 more
TL;DR: It is shown for the first time that even though TgMT mice were more susceptible to KA, the cerebral MT‐I overexpression decreases the hippocampal inflammation and delayed neuronal degeneration and cell death as measured 3 days after KA administration, and indicates thatMT‐I therapy could be used against neurological disorders.
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Altered Central Nervous System Cytokine-Growth Factor Expression Profiles and Angiogenesis in Metallothionein-I+II Deficient Mice:
Milena Penkowa,Javier Carrasco,Mercedes Giralt,Amalia Molinero,Joaquin Hernandez,Iain L. Campbell,Juan Hidalgo +6 more
TL;DR: The results suggest that the MT-I+II isoforms have major regulatory functions in the brain inflammatory response to injury, especially in the angiogenesis process.
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Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression.
TL;DR: The effects of LPS on hepatic MT-I gene expression are mediated by IL-6 and involve the activation of STAT-binding to the proximal promoter.