Javier Luque

TL;DR: On treatment with lithium alkyl (or aryl) cyanocuprates, these chiral building blocks undergo conjugate addition to give enantiopure trans-3,4-substituted 2-piperidone derivatives in high yield and stereoselectivity.

TL;DR: The collective expression changes observed within some functional groups of genes indicate that LECs in cirrhotic livers may contribute to lymphangiogenesis, enhancement of fibrogenesis and inflammatory processes, changes in cell-cell interaction with up-regulation of adherens junction proteins, and alterations in the intrahepatic vascular tone because of the down- regulation of genes involved in vasodilatation.

TL;DR: In this article, the 1,2-or 1,4-addition between amines and α,β-unsaturated aldehydes concerning the pyridine and imidazole moieties is discussed in the light of these results.

TL;DR: In this article, the authors investigated the structure, tautomeric preferences, base-pairing ability, stacking interactions, and HOMO-LUMO gaps of the naphto-bases.

TL;DR: In this paper, a strategy that incorporates in the macromolecular, non-polarizable CHARMM force field models of atomic charges and polarizabilities determined from high-level quantum mechanical calculations is probed in the paradigmatic case of metal ion complexes.