J
Javier Menárguez
Researcher at Hospital General Universitario Gregorio Marañón
Publications - 77
Citations - 3135
Javier Menárguez is an academic researcher from Hospital General Universitario Gregorio Marañón. The author has contributed to research in topics: Lymphoma & Follicular lymphoma. The author has an hindex of 30, co-authored 69 publications receiving 2970 citations. Previous affiliations of Javier Menárguez include Complutense University of Madrid.
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Journal ArticleDOI
Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays
Juan F. García,Francisca I. Camacho,Manuel M. Morente,Máximo Fraga,Carlos Montalbán,Tomás Álvaro,Carmen Bellas,Angel Castaño,Ana Díez,Teresa Flores,Carmen San Martín,Miguel A. Martinez,Francisco Mazorra,Javier Menárguez,Maria J Mestre,Manuela Mollejo,Ana I. Sáez,Lydia Sánchez,Miguel A. Piris +18 more
TL;DR: Hodgkin and Reed-Sternberg cells harbor concurrent and overlapping alterations in the major tumor suppressor pathways and cell-cycle checkpoints, which appears to determine the viability of the tumoral cells and the clinical outcome.
Journal Article
The Molecular Signature of Mantle Cell Lymphoma Reveals Multiple Signals Favoring Cell Survival
Nerea Martinez,Francisca I. Camacho,Patrocinio Algara,Antonia Rodriguez,Ana Dopazo,Elena Ruiz-Ballesteros,Paloma Martín,Jose A. Martinez-Climent,Javier García-Conde,Javier Menárguez,Fernando Solano,Manuela Mollejo,Miguel A. Piris +12 more
TL;DR: MCL seems to combine a disease-specific signature and different sets of genes of which the expression is associated with key clinical, molecular, and immunophenotypical events, which yields a gene-expression based survival predictor.
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Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma. Clinicopathological study and evaluation of the prognostic factors in 143 patients
Carlos Montalbán,M. J. Castrillo,Víctor Abraira,M. Serrano,Carmen Bellas,Miguel A. Piris,Rafael Carrión,Miguel A. Cruz,José García Laraña,Javier Menárguez,Francisco Gomez-Marcos,C. Rivas +11 more
TL;DR: A large retrospective series aiming to confirm whether the histological groups of gastric MALT lymphoma confer different clinical features and behavior and to analyze the prognostic factors in patients shows striking clinical and prognostic differences.
Journal ArticleDOI
Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases.
Manuela Mollejo,Javier Menárguez,Lloret E,Sánchez A,Elias Campo,Patrocinio Algara,Eva Cristobal,Esther María Sánchez Sánchez,M A Piris +8 more
TL;DR: The study showed the critical parameters for their recognition to be morphological, including macroscopic micronodularity and the constant presence of white- and red-pulp infiltration, marginal zone pattern, and plasmacytic differentiation.
Journal ArticleDOI
Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma.
Abel Sánchez-Aguilera,Carlos Montalbán,Paloma de la Cueva,Lydia Sanchez-Verde,Manuel M. Morente,Mónica García-Cosío,José García-Laraña,Carmen Bellas,Mariano Provencio,Vicens Romagosa,Alberto Fernández de Sevilla,Javier Menárguez,Pilar Sabin,Maria J Mestre,Miguel Méndez,Manuel F. Fresno,Concepción Nicolás,Miguel A. Piris,Juan F. García +18 more
TL;DR: Genes related to tumor microenvironment, cell growth/apoptosis, and regulation of mitosis are associated with treatment response and outcome of patients with HL.