J
Jayden A. Smith
Researcher at University of Cambridge
Publications - 30
Citations - 1258
Jayden A. Smith is an academic researcher from University of Cambridge. The author has contributed to research in topics: Ruthenium & Transplantation. The author has an hindex of 18, co-authored 30 publications receiving 981 citations. Previous affiliations of Jayden A. Smith include Trinity College, Dublin & Wellcome Trust.
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Journal ArticleDOI
Metal complexes as structure-selective binding agents for nucleic acids
TL;DR: The present review addresses the range and biological significance of non-duplex structures that are found in DNA and RNA, as well as the specific types of metal complexes that recognise these structural features.
Journal ArticleDOI
Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand
James P. Hall,Kyra O'Sullivan,Abeer Naseer,Jayden A. Smith,John M. Kelly,Christine J. Cardin +5 more
TL;DR: A crystal structure is described of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51° kinking of the double helix.
Journal ArticleDOI
Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication
Stefano Pluchino,Jayden A. Smith +1 more
TL;DR: This issue, Jeppesen et al. characterize exosomes following a strict isolation protocol and in so doing challenge several of the accepted properties of these agents of intercellular communication.
Journal ArticleDOI
Parkinson's disease, aging and adult neurogenesis: Wnt/β-catenin signalling as the key to unlock the mystery of endogenous brain repair.
Bianca Marchetti,Cataldo Tirolo,Francesca L'Episcopo,Salvatore Caniglia,Nunzio Testa,Jayden A. Smith,Stefano Pluchino,M.F. Serapide +7 more
TL;DR: Harnessing WβC‐signalling in the aged PD brain can restore neurogenesis, rejuvenate the microenvironment, and promote neurorescue and regeneration.
Journal ArticleDOI
Neural stem cells traffic functional mitochondria via extracellular vesicles
Luca Peruzzotti-Jametti,Joshua D. Bernstock,Joshua D. Bernstock,Cory M. Willis,Giulia Manferrari,Rebecca Rogall,Erika Fernandez-Vizarra,James C Williamson,James C Williamson,Alice Braga,Aletta Van Den Bosch,Tommaso Leonardi,Tommaso Leonardi,Grzegorz Krzak,Ágnes Kittel,Cristiane Benincá,Nunzio Vicario,Nunzio Vicario,Sisareuth Tan,Carlos Bastos,Iacopo Bicci,Nunzio Iraci,Nunzio Iraci,Jayden A. Smith,Ben Peacock,Karin H. Muller,Paul J. Lehner,Paul J. Lehner,Edit I. Buzás,Nuno Faria,Massimo Zeviani,Christian Frezza,Alain Brisson,Nicholas J Matheson,Nicholas J Matheson,Carlo Viscomi,Stefano Pluchino +36 more
TL;DR: In this article, the authors investigated the hypothesis that NSCs release and traffic functional mitochondria via extracellular vesicles (EVs) to restore mitochondrial function in target cells and found that the transfer of these mitochondria from EVs to mtDNA-deficient L929 Rho0 cells rescued mitochondrial function and increased Rho 0 cell survival.