J
Jayyosi Zaid
Researcher at Hoffmann-La Roche
Publications - 4
Citations - 493
Jayyosi Zaid is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Tumor necrosis factor alpha & In vivo. The author has an hindex of 4, co-authored 4 publications receiving 492 citations.
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Patent
Di-aryl-acid derivatives as PPAR receptor ligands
Jayyosi Zaid,Gerard M. Mcgeehan,Kelley Michael F,Richard Labaudiniere,Litao Zhang,Groneberg Robert D,Mcgarry Daniel G,Thomas J. Caulfield,Anne Minnich,Mark Bobko +9 more
TL;DR: The diaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders are useful as agonists or antagonists of the PPAR receptor as mentioned in this paper.
Journal ArticleDOI
Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats.
Kathryn O. Cooper,Linda M. Reik,Jayyosi Zaid,S. Bandiera,M. Kelley,Dene E. Ryan,R. Daniel,S. A. Mccluskey,Wayne Levin,Paul E. Thomas +9 more
TL;DR: The studies show that constitutive expression and induction of steroid-inducible cytochrome P450s may vary as a function of age.
Journal ArticleDOI
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy.
Iain Mcfarlane Mclay,Frank Halley,John E. Souness,Jeffrey Mckenna,V. Benning,Mark A. Birrell,Brenda J. Burton,Maria G. Belvisi,Collis Alan John,Alex Constan,Martyn Foster,David J Hele,Jayyosi Zaid,Michael F. Kelley,Chris Maslen,Glen K. Miller,Marie-Claude Ouldelhkim,Kenneth Page,Simon Phipps,Kenneth Pollock,Barry Porter,Andrew J. Ratcliffe,Elisabeth J. Redford,Stephen E Webber,Bryan Slater,Véronique Thybaud,Nicola E. Wilsher +26 more
TL;DR: The data from the SCW disease model suggests that RPR200765A could exhibit a profile of disease modifying activity in rheumatoid arthritis (RA) patients which is not observed with current drug therapies.
Journal ArticleDOI
Promotion of Colon Tumors in C57BL/6J-APCmin/+ Mice by Thiazolidinedione PPARγ Agonists and a Structurally Unrelated PPARγ Agonist
TL;DR: The results indicate that the tumor-promoting effect of PPAR γ agonists in the colon of C57BL/6J-APCmin/+ mice is likely related to the pharmacological activity of this group of drugs and not the thiazolidinedione structure.