W
Wayne Levin
Researcher at Hoffmann-La Roche
Publications - 228
Citations - 17629
Wayne Levin is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cytochrome & Microsome. The author has an hindex of 71, co-authored 228 publications receiving 17515 citations. Previous affiliations of Wayne Levin include Roche Institute of Molecular Biology & National Institutes of Health.
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Journal ArticleDOI
An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels.
TL;DR: 3,3′,5,5′-tetramethylbenzidine-H2O2 as a stain for the peroxidase activity of cytochrome P-450 in sodium dodecyl sulfate polyacrylamide gels can be used to detect very low levels of heme-associated peroxIDase activity.
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The P450 gene superfamily: recommended nomenclature.
Daniel W. Nebert,Milton Adesnik,Minor J. Coon,Ronald W. Estabrook,Frank J. Gonzalez,F P Guengerich,Irwin C. Gunsalus,Eric F. Johnson,Byron Kemper,Wayne Levin +9 more
TL;DR: A nomenclature for the P450 gene superfamily is proposed based on evolution, and recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numeral for individual genes.
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The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci
Daniel W. Nebert,David R. Nelson,Milton Adesnik,Minor J. Coon,Ronald W. Estabrook,Frank J. Gonzalez,F. Peter Guengerich,Irwin C. Gunsalus,Eric F. Johnson,Byron Kemper,Wayne Levin,Ian Phillips,Ryo Sato,Michael R. Waterman +13 more
TL;DR: A modest revision of the initially proposed nomenclature of the P450 superfamily is described specifically for the human and mouse chromosomal loci, with the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450."
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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
M. K. Buening,P. G. Wislocki,Wayne Levin,Haruhiko Yagi,Dhiren R. Thakker,H. Akagi,M. Koreeda,D M Jerina,Allan H. Conney +8 more
TL;DR: Differences in the carcinogenic activities of optically active isomers of a polycyclic hydrocarbon diol epoxide are demonstrated by testing the tumorigenicities and activity of benzo[a]pyrene and the other three optically pure isomers.
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Purification and characterization of hepatic microsomal cytochrome P-450
Dene E. Ryan,Wayne Levin +1 more
TL;DR: Article de synthese sur le cytochrome P450, sa purification et la caracterisation de ses proprietes structurales (electrophorese gel), immunologiques, metaboliques (activite enzymatique), extension a une etude interspecifique