J
Jean A. Hamilton
Researcher at Indiana University
Publications - 20
Citations - 862
Jean A. Hamilton is an academic researcher from Indiana University. The author has contributed to research in topics: Crystal structure & Picrate. The author has an hindex of 14, co-authored 20 publications receiving 846 citations.
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Journal ArticleDOI
Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation.
TL;DR: The results provide the first evidence that there are at least two isoenzymes of PDP in mammals that are different with respect to tissue distribution and kinetic parameters and, therefore, are likely to be different functionally.
ComponentDOI
The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30→Met variant to 1.7-Å resolution
Jean A. Hamilton,L.K. Steinrauf,Bradford C. Braden,Juris J. Liepnieks,Merrill D. Benson,Gosta Holmgren,Ola Sandgren,Lars Steen +7 more
TL;DR: The x-ray crystal structures of transthyretin (prealbumin) and the amyloidogenic Val-30-Met variant have been refined at 1.7-A resolution to R-values of 0.168 and 0.179.
Journal ArticleDOI
Structure of Pyruvate Dehydrogenase Kinase: NOVEL FOLDING PATTERN FOR A SERINE PROTEIN KINASE*
C. Nicklaus Steussy,Kirill M. Popov,Melissa M. Bowker-Kinley,Robert B. Sloan,Robert A. Harris,Jean A. Hamilton +5 more
TL;DR: Analysis of the structure of mitochondrial pyruvate dehydrogenase kinase isozyme 2 reveals this C-terminal domain to be very similar to the nucleotide-binding domain of bacterial histidine kinases, but the catalytic mechanism appears similar to that of the eukaryotic serine kinases and ATPases.
Journal ArticleDOI
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia.
TL;DR: The Thyroxine-binding sites of the Thr-109 and Met-30 variants and of the normal protein are compared, and the results suggest that the variation in affinity for thyroxine between the three proteins may arise from differences in the size of the binding pocket.