Jean A. Niles

TL;DR: It is found that AC lung allowed for better retention of cells with more differentiation of mESCs into epithelial and endothelial lineages and highlights the critical role played by matrix or scaffold-associated cues in guiding ESC differentiation toward lung-specific lineages.

TL;DR: The isolation and characterization of a population of adult-derived or somatic lung progenitor cells from adult mammalian lung tissue and the promotion of alveolar tissue growth by these cells (both in vitro and in vivo) after seeding onto synthetic polymer scaffolds are described.

TL;DR: Examination of scaffolds produced using a variety of detergents indicated that detergent choice influenced human immune response in terms of T cell activation and chemokine production.

TL;DR: The development of an in vitro artificial bone marrow based on a 3D scaffold with inverted colloidal crystal (ICC) geometry mimicking the structural topology of actual bone marrow matrix being shown to be critical for production of B cells and antigen-specific antibodies is reported.

TL;DR: The present studies showed that Fas-FasL signaling plays a major role in the induction of apoptosis in lymphocytes after exposure to IAV, which likely represents a part of an overall beneficial immune response but could be a possible mechanism of disease pathogenesis.