J
Jean E. Schwarzbauer
Researcher at Princeton University
Publications - 154
Citations - 12375
Jean E. Schwarzbauer is an academic researcher from Princeton University. The author has contributed to research in topics: Fibronectin & Extracellular matrix. The author has an hindex of 58, co-authored 149 publications receiving 11529 citations. Previous affiliations of Jean E. Schwarzbauer include Massachusetts Institute of Technology & University of Washington.
Papers
More filters
Journal ArticleDOI
A single cysteine, Cys-64, is essential for assembly of tenascin-C hexabrachions
TL;DR: The results show that trimers are an intermediate of tenascin-C assembly and that Cys-64 is essential for formation of hexabrachions, and that monomers were the major extracellular form.
Journal ArticleDOI
A simple nanoscale interface directs alignment of a confluent cell layer on oxide and polymer surfaces
Patrick E. Donnelly,Casey M. Jones,Stephen B. Bandini,Shivani Singh,Jeffrey Schwartz,Jean E. Schwarzbauer +5 more
TL;DR: In this method, a volatile zirconium alkoxide complex is first deposited at reduced pressure onto a surface pattern that is prepared by photolithography; the substrate is then heated to thermolyze the organic ligands to form surface-bound zIRconium oxide patterns.
Journal ArticleDOI
Mechanistic insights into the cellular effects of a novel FN1 variant associated with a spondylometaphyseal dysplasia.
E.B. Cadoff,Ruth Sheffer,S. Wientroub,S. Wientroub,D. Ovadia,D. Ovadia,Vardiella Meiner,Jean E. Schwarzbauer +7 more
TL;DR: Immunofluorescence and immunoblotting analyses show that mutant fibroblasts assemble significantly lower amounts of FN matrix than wild‐type cells, and mutant FN was preferentially retained within the endoplasmic reticulum.
Journal ArticleDOI
The cartilage-specific (V+C)- fibronectin isoform exists primarily in homodimeric and monomeric configurations.
Nancy Burton-Wurster,Rina Gendelman,Hao Chen,Da Nian Gu,Jonathan Wendell Tetreault,George Lust,Jean E. Schwarzbauer,James N. MacLeod +7 more
TL;DR: The unique dimerization pattern of (V+C)(-) fibronectin is consistent with this isoform having specialized functional properties in situ that are important for either the structural organization and biomechanical properties of cartilage matrix or regulation of a chondrocytic phenotype.
Journal ArticleDOI
mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites
TL;DR: RNAi depletion of both mig-38 and ina-1 enhanced the loss of turning phenotype indicating a genetic interaction between these genes, and a model to explain the dual role of MIG-38 in motility and turning is proposed.