J
Jean-François Savouret
Researcher at Paris Descartes University
Publications - 68
Citations - 4662
Jean-François Savouret is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Receptor & Resveratrol. The author has an hindex of 33, co-authored 68 publications receiving 4520 citations. Previous affiliations of Jean-François Savouret include University of Paris & French Institute of Health and Medical Research.
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Journal ArticleDOI
A Method for Isolation of Intact, Translationally Active Ribonucleic Acid
Guy Cathala,Jean-François Savouret,Bernardita Mendez,Brian L. West,Michael Karin,Joseph Martial,John D. Baxter +6 more
TL;DR: A method for isolation of large, translationally active RNA species is presented and yields large mRNA precursors up to 10 kb and mRNA species which translate very well, however, small RNA species are recovered with a poor yield.
Journal Article
Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity.
Robert F. Casper,Monique Quesne,Ian M. Rogers,Takuhiko Shirota,André Jolivet,Edwin Milgrom,Jean-François Savouret +6 more
TL;DR: It is shown that a wine component, resveratrol (3,5,4'-trihydroxystilbene), is a competitive antagonist of dioxin and other AhR ligands.
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Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene.
Jean-François Savouret,A. Bailly,Micheline Misrahi,Claudine Rauch,G. Redeuilh,Anne Chauchereau,Edwin Milgrom +6 more
TL;DR: Use of deletion mutants of the progesterone receptor showed that the steroid binding and the DNA binding domains were necessary for down‐regulation whereas deletions of various parts of the N‐terminal domain were without effect.
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Resveratrol and cancer: a review
TL;DR: The various properties of the stilbene phytoalexin Resveratrol provide interesting new avenues of research in the field of chemoprevention and chemotherapy, with particular emphasis on xenobiotic-related carcinogenesis.
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Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.
Ariel Revel,Hila Raanani,Edward V. Younglai,Jing Xu,Ian M. Rogers,R. N. N. Han,Jean-François Savouret,Robert F. Casper +7 more
TL;DR: All BaP‐induced effects could be prevented by resveratrol, suggesting a possible chemopreventive role for this natural phytoalexin against the development of lung cancer.