C
Claudine Rauch
Researcher at University of Rennes
Publications - 24
Citations - 1485
Claudine Rauch is an academic researcher from University of Rennes. The author has contributed to research in topics: Gene & Progesterone receptor binding. The author has an hindex of 14, co-authored 23 publications receiving 1394 citations. Previous affiliations of Claudine Rauch include French Institute of Health and Medical Research.
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Journal ArticleDOI
Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene.
Jean-François Savouret,A. Bailly,Micheline Misrahi,Claudine Rauch,G. Redeuilh,Anne Chauchereau,Edwin Milgrom +6 more
TL;DR: Use of deletion mutants of the progesterone receptor showed that the steroid binding and the DNA binding domains were necessary for down‐regulation whereas deletions of various parts of the N‐terminal domain were without effect.
Journal ArticleDOI
Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression.
Brian F. Coles,Fabrice Morel,Claudine Rauch,Wolfgang W. Huber,Mihi Yang,Candee H. Teitel,Bridgett Green,Nicholas P. Lang,Fred F. Kadlubar +8 more
TL;DR: Because the polymorphism in hGSTA1 correlates with hG STA1 and h GSTA2 expression in liver, and hGstA1-1 andhGSTa2-2 exhibit differential catalysis of the detoxification of carcinogen metabolites and chemotherapeutics,The polymorphism is expected to be of significance for individual risk of cancer or individual response to chemotherAPEutic agents.
Journal ArticleDOI
Gene and Protein Characterization of the Human Glutathione S-Transferase Kappa and Evidence for a Peroxisomal Localization
Fabrice Morel,Claudine Rauch,Elise Petit,Amélie Piton,Nathalie Théret,Brian F. Coles,André Guillouzo +6 more
TL;DR: The structure and chromosomal location of the human GST Kappa 1 (hGSTK1) gene is determined, the protein is characterized, and its subcellular localization is demonstrated.
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The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.
TL;DR: It may be postulated that hGSTA1 genotyping will be of importance to determine individual susceptibility to certain cancers or the efficacy of chemotherapeutics via its effect on hG STA1 expression.
Journal ArticleDOI
Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells.
Hanane Akhdar,Pascal Loyer,Pascal Loyer,Claudine Rauch,Claudine Rauch,Anne Corlu,Anne Corlu,André Guillouzo,André Guillouzo,Fabrice Morel,Fabrice Morel +10 more
TL;DR: It is demonstrated for the first time that 5-FU activates the Nrf2/ARE pathway which in turn induces cytoprotective genes and modulates chemosensitivity of HT-29 colon cancer cells.